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EC number: 947-892-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- Please find the attached justification.
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 500 mg/L
- Remarks on result:
- other: Result of RA Source record CAS 1328-53-6 (BASFSE, 1988); no effects up to the limit of water solubility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 50 mg/L
- Remarks on result:
- other: Result of RA Source record Phthalocyanine (Jancula, 2008); likely no effects up to the limit of water solubility
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- OECD 202 limit test. No detail on procedure followed, only results presented.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Test substance: Phtalocyanin-AI-Komplex
- Code No.: Tinolux BBS
- Batch-No.: 021422D7
- Purity: 11.5 (%)
- Appearance: blue liquid
- Solubility: miscible
- Storage: room temperature
- Expiration date: not indicated by the sponsor - Analytical monitoring:
- not specified
- Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Test type:
- not specified
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Nominal and measured concentrations:
- - Nominal concentrations: 0 (control) and 100 mg/L
- Measured concentrations: not reported. - Details on test conditions:
- TEST SYSTEM
- No. of organisms per vessel: 10
- No. of vessels per concentration: 2
- No. of vessels per control: 2
EFFECT PARAMETERS MEASURED:
Mobility after 24 and 48 hours - Reference substance (positive control):
- not specified
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 11.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Details on results:
- No immobility observed during the test period.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Nominal test concentrations were not analytically verified.
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Version / remarks:
- May, 1984
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPP 72-2 (Aquatic Invertebrate Acute Toxicity Test)
- Qualifier:
- according to guideline
- Guideline:
- ISO 6341 (Water quality - Determination of the Inhibition of the Mobility of Daphnia magna Straus (Cladocera, Crustacea))
- Version / remarks:
- 1979
- GLP compliance:
- no
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Heliogen Gruen 8730
- Batch No.: BW 32
- Purity: 98%
- Water solubility: slightly - Analytical monitoring:
- no
- Vehicle:
- yes
- Remarks:
- Tween 80
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: the substance was added as a supplement to Tween 80 and subsequently diluted with water. This stock contained 500 mg/L test substance and 100 mg/L vehicle. The stock was stirred for 10 minutes at 20 °C. The stock solution was further diluted with water to obtain a dilution series of which 10 mL was added to the test vessels to obtain the required nominal test concentrations. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Strain: Straus
- Source/culture: The used strain of daphnids was obtained from the Institut National de Recherche Chimique, Appliquee, France, and has been further cultured in the BASF laboratory for environmental analysis and ecology since the beginning of 1978.
- Age: 2 - 24 h
CULTURE CONDITIONS
- Same as test conditions - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- 2.7 ± 0.5 mmol/L
- Test temperature:
- 19 - 21 °C
- pH:
- ca. 7.4 - 7.8
- Dissolved oxygen:
- ca. 6.5 - 9.4 mg/L
- Conductivity:
- 550 - 650 µSiemens/cm
- Nominal and measured concentrations:
- - Nominal concentrations: 0 (control), 62.5, 125, 250 and 500 mg/L
- Measured concentrations: no analysis performed. - Details on test conditions:
- TEST SYSTEM
- Test vessel: glass with flat bottom
- Fill volume: 10 mL
- Aeration: no, although test medium was aerated with oil-free air and left to stabilize at least 24 hours prior to use
- No. of organisms per vessel: 5
- No. of vessels per concentration: 4
- No. of vessels per control: 4
TEST MEDIUM / WATER PARAMETERS
- Medium: filtered and dechlorinated tap water
- Ca/mg ratio: 4:1
- Na/K ratio: 4:1
- Culture medium different from test medium: no
OTHER TEST CONDITIONS
- Photoperiod: day/night rhythm of 16:8 hours
- Light intensity: diffuse light (ca. 5 µE·m-2·s-1 at a wavelength of 400-750 nm)
EFFECT PARAMETERS MEASURED:
Mobility after 0, 3, 6, 24 and 48 hours
VEHICLE CONTROL PERFORMED:
yes - Reference substance (positive control):
- no
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 500 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mobility
- Remarks on result:
- other: no effects up to the limit of water solubility
- Details on results:
- Both at test concentrations of 62.5 mg/L and 500 mg/L 1 of 20 daphnids was found immobile at 48 hours after exposure. No other abnormailities are reported.
- Validity criteria fulfilled:
- yes
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- ISO 6341 (Water quality - Determination of the Inhibition of the Mobility of Daphnia magna Straus (Cladocera, Crustacea))
- Version / remarks:
- 1996
- GLP compliance:
- no
- Specific details on test material used for the study:
- The test substance was synthesized by Research Institute of Organic Synthesis (VUOS PLC), Rybitvi, Czech republic.
- Analytical monitoring:
- no
- Vehicle:
- not specified
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- No information available.TEST ORGANISM
- Common name: water flea
- Age of parental stock (mean and range, SD): < 24h
- Feeding during test: none - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Test temperature:
- 21 ± 2 °C
- Nominal and measured concentrations:
- - Nominal concentrations: 0 (control), 0.01, 0.1, 1, 10 and 50 mg/L
- Measured concentrations: concentrations were not analytically verified - Details on test conditions:
- TEST SYSTEM
- Test vessel: polystyrene plates with 10 mL vessels#
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Medium used: standard exposure solution containing basic inorganic salts (according to ISO 6341 (1996)
OTHER TEST CONDITIONS
- Light intensity: 20 µmol·m-2·s-1
- Photoperiod: 14/10-h light/dark period
EFFECT PARAMETERS MEASURED: mobility, after 48 hours - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 50 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: likely no effects up to the limit of water solubility
- Details on results:
- No effects observed in control and any treatment.
- Results with reference substance (positive control):
- Not reported.
- Reported statistics and error estimates:
- Linear regression analysis of inhibition percentage versus extract concentration along with the 95% confidence intervals.
- Validity criteria fulfilled:
- yes
Referenceopen allclose all
Description of key information
No effects were observed up to the limit of water solubility.
Key value for chemical safety assessment
Additional information
A study performed with the substance itself was considered to contain insufficient documentation and was thus by itself not suitable for classification purposes. Therefore, additional data on close structural analogues is presented as part of a weight of evidence approach. Although no analytical verification of test concentrations has been performed in these studies, it may be assumed that test organisms were exposed to the water-soluble fraction of test substance for the entire exposure period: the stability of these molecules play an important role in their application; no hydrolysis, photolysis, adsorption, biodegradation or evaporation of this molecule in/from the test medium is expected.
The acute toxicity to aquatic invertebrates was determined for the close structural analogue Pigment Green 7 (CAS 1328-53-6) in a study according to EU method C.2 (BASF 1988). In this study daphnids (D. magna, 20 per concentration) were exposed to nominal concentrations of 0 (control), 62.5, 125, 250 and 500 mg/L for 48 hours under static conditions. Concentrations were not analytically verified. Immobilization was recorded after 0, 3, 6, 24 and 48 hours after application. At concentrations 62.5 and 500 mg/L one daphnid was immobile after 48 hours. Other, no mortality occurred. Based on these findings the 48-h EC50 value was determined at > 500 mg/L.
Furthermore, Jancula et al (2008) studied a close structural analogue (Me = Al; R1,2 =SO3Na, R3,4 = H) in a static daphnia test, the methods equivalent or similar to ISO 6431. In this test, dapnnids (D. magna, 20 per concentration) were exposed to test concentrations of 0, 0.01, 0.1, 1, 10 and 50 mg/L for 48 hours. No information on analytical confirmation of test concentrations is presented. Immobilization was determined after 48 hours. No immobilization was observed up to the highest tested concentration. Based on these findings, the 48-h EC50 value was determined to be > 50 mg/L.
In the study performed with the actual test substance itself, the acute toxicity to aquatic invertebrates was determined in a limit test according to OECD TG 202, where daphnids (D. magna, 20 per concentration) were exposed to nominal concentrations of 0 and 100 mg/L for 48 hours under static conditions (BASF 1998). No information on analytical confirmation is presented. Immobilization was determined after 24 and 48 hours exposure. No immobilization was observed at 100 mg/L or the blank. Based on these findings the 48-h EC50 value was, considering the purity of the compound, determined at > 11.5 mg/L (nominal concentration 100 mg/L).
The target substance and two close structural analogues show no adverse effects in aquatic invertebrates. Overall, no effects were observed up to the limit of water solubility and thus the substance is not considered to be harmful to aquatic invertebrates.
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