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Diss Factsheets
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EC number: 209-091-3 | CAS number: 555-32-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
No repeated dose toxicity data are available for aluminium tribenzoate, the endpoint is filled by read across (rationale is attached in section 13). There are several publications and evaluations available for both the benzoate and aluminium ion. Based on the results of a feeding study with benzoic acid over 4 generations (chosen as key study), the NOAEL was established to be at least 1% in feed, which correlates to approximately 430 mg aluminium tribenzoate/kg bw/day.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Link to relevant study records
- Endpoint:
- chronic toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- The rationale to read across the data is attached in section 13.
- Reason / purpose for cross-reference:
- read-across source
- Limit test:
- no
- Mortality:
- no mortality observed
- Description (incidence):
- The average survival (F0 and F1-generation) was slightly increased in the dosed groups compared to the control groups (average lifespan in days: 785 ± 20, 899 ± 28 and 827 ± 25 for the control group and the groups dosed at 0.5% and 1,0%, respectively).
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- no effects observed
- Food efficiency:
- no effects observed
- Organ weight findings including organ / body weight ratios:
- no effects observed
- Gross pathological findings:
- no effects observed
- Histopathological findings: non-neoplastic:
- no effects observed
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- >= 1 other: %
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: No adverse effects seen up to and including 1% benzoic acid in feed.
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- >= 430 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Remarks:
- Aluminium tribenzoate
- Sex:
- male/female
- Basis for effect level:
- other: No adverse effects seen up to and including highest dose tested.
- Critical effects observed:
- no
- Conclusions:
- Based on the results of a feeding study with benzoic acid over 4 generations, the NOAEL was established to be at least 1% in feed, which correlates to approximately 400 mg/kg bw/day. This result is read across to alumnium tribenzoate (see rationale attached in section 13).
Reference
Based on the default values as proposed in TNO report V98 the average body weight rat in a chronic study is appr. 375 g (male and female). According to the authors, the average intake was approximately 150 mg benzoic acid/ rat, which corresponds to an exposure of appr. 400 mg/kg bw/day. In order to adjust this value from the source chemical (benzoic acid) to the target chemical (aluminium tribenzoate), the following calculation is used: NOAEL benzoate = 400 mg/kg bw/d. Based on a molecular weight of aluminium tribenzoate (MW=390.33), the benzoate ion (MW=121.11) has a weight percentage of 93.09%. Therefore, the adjusted NOAEL for aluminium tribenzoate is calculated to be 430 mg/kg bw/day ((400 mg/kg bw/day/ 93.09)*100).
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 430 mg/kg bw/day
- Study duration:
- chronic
- Species:
- rat
- Quality of whole database:
- The key study was considered to be reliable (Klimisch 2).
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Based on the results of a feeding study with benzoic acid over 4 generations, the NOAEL was established to be at least 1% in feed, which correlates to approximately 400 mg/kg bw/day. This result is read across to alumnium tribenzoate (see rationale attached in section 13). The corresponding NOAEL is appr 430 mg/kg bw/day, based on no adverse effects seen at the highest dose tested.
Justification for classification or non-classification
Based on the available data, aluminium tribenzoate is not classified for repeated dose toxicity according to CLP Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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