Registration Dossier
Registration Dossier
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EC number: 265-805-3 | CAS number: 65520-42-5
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
The whole dataset of mutagenicity data (comprising read-across), lead to the conclusion that bis[2-[2-(2-butoxyethoxy)ethoxy]ethyl] hydrogen glutarate is not of concern for mutagenicity.
Link to relevant study records
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- Adipic acid diesters category. See attached report.
- Key result
- Remarks on result:
- other: no mutagrenic potential (based on read-across)
- Conclusions:
- According to the category read-across approach, no genotoxic potential is expected for the adipic acid diesters category and bis{2-[2-(2-butoxyethoxy)ethoxy]ethyl} hydrogen glutarate.
- Endpoint:
- in vitro gene mutation study in mammalian cells
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- Adipic acid diesters category. See attached report.
- Key result
- Remarks on result:
- other: no mutagrenic potential (based on read-across)
- Conclusions:
- According to the category read-across approach, no genotoxic potential is expected for the adipic acid diesters category and bis{2-[2-(2-butoxyethoxy)ethoxy]ethyl} hydrogen glutarate.
- Endpoint:
- in vitro cytogenicity / chromosome aberration study in mammalian cells
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- Adipic acid diesters category. See attached report.
- Key result
- Remarks on result:
- other: no mutagrenic potential (based on read-across)
- Conclusions:
- According to the category read-across approach, no genotoxic potential is expected for the adipic acid diesters category and bis{2-[2-(2-butoxyethoxy)ethoxy]ethyl} hydrogen glutarate.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
Justification for classification or non-classification
Basing on the available data, bis[2-[2-(2-butoxyethoxy)ethoxy]ethyl] hydrogen glutarate is not classified for mutagenicity according to Regulation (EC) n. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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