Registration Dossier
Registration Dossier
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EC number: 249-670-8 | CAS number: 29508-47-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer-reviewed journal
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VI
- Author:
- HENRY F. SMYTH, CHARLES P. CARPENTER,CARROL S. WEIL,URBANO C. POZZANI, and JEAN. A. STRIEGEL
- Year:
- 1 962
- Bibliographic source:
- American Industrial Hygiene Association Journal, 23:2,pg 95-107, 1962
- Reference Type:
- other: authoritative database
- Title:
- Acute oral toxicity study of 1-methyl-diethylenediamine (109-01-3) in Rat
- Author:
- U.S. National Library of Medicine
- Year:
- 2 017
- Bibliographic source:
- Chemidplus Database,U.S. National Library of Medicine,2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Acute Oral toxicity test was carried out to study the effects of 1-Methylpiperazine (109-01-3) on rats.
- GLP compliance:
- not specified
- Test type:
- other: no data available
- Limit test:
- no
Test material
- Reference substance name:
- 1-methylpiperazine
- EC Number:
- 203-639-5
- EC Name:
- 1-methylpiperazine
- Cas Number:
- 109-01-3
- Molecular formula:
- C5H12N2
- IUPAC Name:
- 1-methylpiperazine
- Details on test material:
- - Name of test material: 1-Methylpiperazine
- Molecular formula: C5H12N2
- Molecular weight: 100.16 g/mol
- Substance type: Organic
- Physical state: Colorless transparent liquid
- Purity: No data
- Impurities (identity and concentrations): No data
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report):1-Methylpiperazine
- Molecular formula :C5H12N2
- Molecular weight :100.1638 g/mol
- Substance type:organic
Test animals
- Species:
- rat
- Strain:
- other: Carworth-Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- other: oral:gastric intubation
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- 2830 mg/kg bw
- No. of animals per sex per dose:
- Total: 5 animals
2830 mg/kg bw : 5 males - Control animals:
- not specified
- Details on study design:
- Details on study design:
- Duration of observation period following administration: 14 days - Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 830 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was observed in treated rats at 2830 mg/kg bw
- Mortality:
- 50% mortality was observed in treated rats at 2830 mg/kg bw
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The lethal concentration (LD50) value for acute oral toxicity test was considered to be 2830 mg/kg bw ,when groups of 5 non-fasted Carworth-Wistar male rats were treated with 1-Methylpiperazine (109-01-3) orally by gastric intubation.
- Executive summary:
Acute oral toxicity study was done in groups of 5 non-fasted,Carworth-Wistar malerats using test material 1-Methylpiperazine(109-01-3) following 14 days of observation period.50% mortality was observed in treated rats at 2830 mg/kg bw.Hence,LD50 value was considered to be 2830 mg/kg bw,when rats were treated with 1-Methylpiperazine(109-01-3)orally by gastric intubation.
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