Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-752-1 | CAS number: 71-41-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
- Principles of method if other than guideline:
- Internal BASF method was used
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Pentan-1-ol
- EC Number:
- 200-752-1
- EC Name:
- Pentan-1-ol
- Cas Number:
- 71-41-0
- Molecular formula:
- C5H12O
- IUPAC Name:
- pentan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): pentanol-1 (n-pentanol)
- Physical state: liquid
- Analytical purity: ca. 99%
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Kisslegg mouse
- Weight at study initiation: mean 29.8 g (male), 25.6 g (female)
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on exposure:
- - Concentration of vehicle (aqueous suspension): 0.5%
- Concentration of test substance in vehicle: 2, 4, 16%
- Applied volume: 10 or 20 ml - Doses:
- 0.2, 0.4, 0.8, 1.6 ml/kg bw (ca. 163, 326, 652, 1304 mg/kg bw assuming a density of 0.815 g/ml)
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Daily recording of signs and symptoms from the day of administration till the end of the observation period. Daily check (twice) for moribund and dead animals (once during the weekend).
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, pathology
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 326 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 0.2 ml/kg bw: no mortalities
0.4 ml/kg bw: 1/5 male within 24 h; 2/5 males within 7 days; 3/5 males within 14 days; 1/5 female within 7 days
0.8 ml/kg bw: 2/5 males within 24 h; 4/5 males within 7 days; 3/5 females within 48 h; 5/5 females within 7 days
1.6 ml/kg bw: 2/5 males within 1 h; 5/5 males within 7 days; 5/5 females within 1 h - Clinical signs:
- 0.2 ml/kg bw: directly after treatment: tachypnea, staggering and abdominal posture; after few minutes: tachypnea and staggering; from ca. 5 hours onwards: squatting posture and tachypnea; nothing abnormal was detectable in surviving animals from day 6 after treatment
0.4 ml/kg bw: directly after treatment: tachypnea, staggering and abdominal posture; after few minutes: atony, intermittent tremor and scampering gait; from ca. 5 hours onwards: squatting posture and tachypnea; nothing abnormal was detectable in surviving animals from day 13 after treatment
0.8 ml/kg bw: First day after treatment: tachypnea, staggering, atony, apathy and dyspnea. Narcosis and squatting posture partly observed; during the following days: squatting; nothing abnormal was detectable in surviving animals from day 12 after treatment
1.6 ml/kg bw: directly after treatment: tachypnea, staggering and abdominal posture; after few minutes: dyspnea and narcosis; after ca. 5 hours: dyspnea; after 2 days: intermittent tremor the 2 last animals died at day 6 - Body weight:
- no abnormality reported
- Gross pathology:
- - Survivors: nothing abnormal detected (with the exception of slightly liver size increase in the 6 animals of the 0.4 ml/kg group)
- Dead animals: loam grey staining (in 7 animals of the 1.6 ml/kg and 6 of the 0.8 ml/kg group); liver congestion hyperemia (in 3 animals of the 1.6 ml/kg and 1 of the 0.4 ml/kg group); atonic gut (in 1animal of the 0.4 ml/kg group); intra-abdominal agglutination (in 1 animal of the 0.4 mg/kg group); venous hyperemia (in 3 of the 0.8 ml/kg group); intra-intestinal diarrheal content (in 1 animal of the 0.4 ml/kg and 3 of the 0.8 ml/kg group).
Any other information on results incl. tables
Original value: LD50 = ca. 0.4 mL/kg bw
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)