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Physical & Chemical properties

Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
December 1999 to Jan 2000
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods
Justification for type of information:
UUID SNIF-2a0dd96c-9a86-36a5-89ab-9aeb1328754b
Date 2010-08-27 03:35:46 BST
Remarks Successfully migrated to IUCLID 5.5 format.
upgraded to IUCLID 6
Qualifier:
according to guideline
Guideline:
other: : Sieving screen. Two replicates of approximately 64 g were used
GLP compliance:
yes
Type of method:
sieving
Type of particle tested:
primary particle
Type of distribution:
mass based distribution
No.:
#1
Size:
> 2 000 µm
Distribution:
0.09 %
No.:
#2
Size:
850 - 2 000 µm
Distribution:
12.24 %
No.:
#3
Size:
500 - 850 µm
Distribution:
70.44 %
No.:
#4
Size:
300 - 500 µm
Distribution:
10.25 %
No.:
#5
Size:
250 - 300 µm
Distribution:
0.72 %
No.:
#6
Size:
150 - 250 µm
Distribution:
5.14 %
No.:
#7
Size:
106 - 150 µm
Distribution:
0.35 %
No.:
#8
Size:
< 106 µm
Distribution:
0.77 %

Particle Size Distribution:

From sieving analysis,approximate distribution is:

 < 1% > 2000µm

 12% 850-2000µm

 70% 500-850µm

 10% 300-500µm

 <10% <300µm

 <1% < 106µm

Mass Median Diameter: Not determined by this method

Conclusions:
The particle size distribution was determined using by a sieve screening technique. A fraction of 0.77% w/w was recorded as passing a 106 micrometer screen.
Particle size distribution (from NCD section 3.0.00):
From sieving analysis, < 1% of the substance by mass passed through a 106 µm sieve. Less than 10% by mass passed through a 300 µm sieve, with almost 70% being trapped in the 500 - 850 µm range.

Description of key information

Analysis was conducted by sieve method therefore mean particle diameter could not be determined. However, the bulk of the sample analysed had a particle size of between 2000μm and 300μm (appromately 90%), although the inhalable fraction is considered to be negligible. Further investigation of the particle size below 100μm is not considered to be necessary. In fact, less than 1% of the particles (by mass) are smaller than 106 μm.

Additional information