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EC number: 203-339-4 | CAS number: 105-86-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Oral (OECD 401), rat: LD50 > 6 mL/kg bw (corresponding to > 5532 mg/kg bw based on a relative density of 0.922 g/cm³)
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- no data on analytical purity of test substance given
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- no data on analytical purity of test substance given
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Females nulliparous and non-pregnant: not specified
- Weight at study initiation: 150 - 200 g
- Fasting period before study: overnight
- Housing: individually
- Diet: commercial diet
- Water: ad libitum - Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 50% (v/v)
- Doses:
- range-finding study: up to 10 mL/kg bw (corresponding to 9220 mg/kg bw based on a relative density of 0.922 g/cm³), not further specified
main study: 6 mL/kg bw (corresponding to 5532 mg/kg bw based on a relative density of 0.922 g/cm³) - No. of animals per sex per dose:
- range-finding study: 5 to 6 animals in total, not further specified
main study: 5 per sex per dose - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: range-finding study: 2 days; main study: 14 days
- Frequency of observations and weighing: range-finding study: Toxic signs and mortality were recorded at 1, 4, 24 and 48 hours.; main study: Toxic signs and mortality were recorded at 1 and 4 hours and then once daily for a period of 14 days.
- Necropsy of survivors performed: yes
- Other examinations performed: toxic signs, gross pathology - Preliminary study:
- No death occurred in rats which received test substance at any dose level up to 10 mL/kg bw.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 6 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: (corresponding to 5532 mg/kg bw based on a relative density of 0.922 g/cm³)
- Mortality:
- One death occurred in a group of five rats receiving 6 mL/kg bw.
- Clinical signs:
- other: Toxic signs of piloerection and ataxia were noted for one rat at 6 mL/kg bw.
- Gross pathology:
- No abnomalities were noted in animals that died following treatment or were killed at termination of the study.
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No 1272/2008
- Conclusions:
- In this acute oral toxicity study in rats a LD50 value of > 6 mL/kg bw (corresponding to > 5532 mg/kg bw based on a relative density of 0.922 g/cm³) was found.
- Executive summary:
The acute oral toxicity of the test substance was assessed in a study similar to OECD Guideline 401 (1971).Based on a preliminary study, groups of 5 male and 5 female rats were given a dose of 6 mL/kg bw via gavage. One animal died at 6 mL/kg bw. Thus, a LD50 > 6 mL/kg bw (corresponding to > 5532 mg/kg bw based on a relative density of 0.922 g/cm³) was determined.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- The available information comprises an adequate and reliable study (Klimisch score 2), and is thus sufficient to fulfil the standard information requirements set out in Annex VII, 8.5, of Regulation (EC) No 1907/2006.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The acute oral toxicity of the test substance was assessed in a study similar to OECD Guideline 401 (1971). Based on a preliminary study, groups of 5 male and 5 female rats were given a dose of 6 mL/kg bw via gavage. One animal died at 6 mL/kg bw. Thus, a LD50 > 6 mL/kg bw (corresponding to > 5532 mg/kg bw based on a relative density of 0.922 g/cm³) was determined.
Justification for classification or non-classification
The available data on acute oral toxicity do not meet the criteria for classification according to Regulation (EC) 1272/2008, and are therefore conclusive but not sufficient for classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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