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EC number: 258-110-1 | CAS number: 52697-38-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
No treatment-related effects on female fertility were seen in the developmental toxicity study. In addition, no treatment-related malformationwere seen in the offspring in this study. The maternal and developmental NOAELs were determined to be >2000 mg/kg bw/day.
Effect on fertility: via oral route
- Endpoint conclusion:
- no study available
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Effects on developmental toxicity
Description of key information
No treatment-related effects were seen in the developmental toxicity study. The maternal and developmental NOAELs were determined to be >2000 mg/kg bw/day.
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Study duration:
- subacute
- Species:
- rat
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Additional information
A study was conducted to determine the developmental toxicity of the test substance (99.61% purity) in rat. Female Sprague Dawley rats (25/dose) were administered by gavage the following concentrations (dissolved corn oil, at a volume of 10 mL/kg bw): 0, 500, 1000 and 2000 mg/kg bw/day from gestational day (GD) 6 to 15. The homogeneity, stability and concentrations of dosing suspensions were analysed and were within acceptable values. Clinical signs were recorded daily and twice daily during the dosing period. Maternal body weight were measured on GD 0, 6, 9, 12, 15, 18 and 20 and food consumption on GD 0-6, 6-9, 9-12, 12-15, 15-18 and 18-20. At scheduled sacrifice on GD 20, the dams were evaluated for body weight, liver and gravid uterine weight. Ovarian corpora lutea were counted and the status of uterine implantation sites (i.e., resorptions, dead fetuses, live fetuses, pre and post-implantations) was recorded. Fetuses were dissected from the uterus, counted, weighted, sexed and examined for external abnormalities as well as for visceral malformations and variations. Sections of the heads were examined for soft tissue craniofacial malformations and variations. All fetuses were eviscerated, fixed in alcohol, and stained with alizarin red S/alcian blue. Intact fetuses were examined for skeletal malformations and variations. Except for green, dark and/or green feces at 500 mg/kg bw/day and above, piloerection at all concentrations (GD 12-20) and vaginal bleeding at 2000 mg/kg bw/day in one dam on GD 15, no other effects were observed. Gestational parameters (e.g. ovarian corpora lutea, uterine implantation sites, resorptions, dead fetuses, live fetuses, pre and post-implantation losses) were not modified by the treatment. Two litters at 500 mg/kg bw/day were fully resorbed; all remaining pregnant animals had one or more live fetuses on GD 20. Fetal body weight was slightly reduced at 2000 mg/kg bw/day with no obvious dose-related trends. Malformations (external and skeletal) were recorded but with no treatment-related patterns of incidence or severity. Under the study conditions, the maternal and developmental NOAELs were determined to be >2000 mg/kg bw/day.
Justification for classification or non-classification
Based on the results of the pre-natal developmental toxicity studies in rats and rabbits, no classification for this endpoint is required according to CLP (EC 1272/2008) criteria.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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