Registration Dossier
Registration Dossier
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EC number: 204-246-1 | CAS number: 118-33-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from peer reviewed journals and authoritative databases
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- TOXICITY AND ECOTOXICITY OF SULFONIC ACIDS: STRUCTURE-ACTIVITY RELATIONSHIP
- Author:
- GREIM H., J. AHLERS, R. BIAS, B. BROECKER, H. HOLLANDER, H.P. GELBKE, H.-J. KLIMISCH, I. MANGELSDORF, A. PAETZ, N SCHGN, G. STROPP, R. VOGEL, C. WEBER, K. ZIEGLER-SKYLAKAKIS and E. BAYER
- Year:
- 1 994
- Bibliographic source:
- Chemosphere. Vol. 28, No. 12, pp. 2203.2236, 1994
- Reference Type:
- secondary source
- Title:
- RTECS - QJ6125000
- Author:
- RTECS® is a United States trademark owned and licensed under authority of the U.S. Government
- Year:
- 1 997
- Bibliographic source:
- RTECS - QJ6125000, RTECS®, review date – September, 1997
- Reference Type:
- review article or handbook
- Title:
- Eye Irritation of 6-Amino-Naphthalene-1,3-Disulfonic Acid
- Author:
- Richard J Lewis, Sr
- Year:
- 2 012
- Bibliographic source:
- SAX's Dangerous properties of industrial material, 12th edition, 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To assess the eye irritation potential of 6-amino-1,3- Naphthalene disulfonic acid in rabbits
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 6-aminonaphthalene-1,3-disulphonic acid
- EC Number:
- 204-246-1
- EC Name:
- 6-aminonaphthalene-1,3-disulphonic acid
- Cas Number:
- 118-33-2
- Molecular formula:
- C10H9NO6S2
- IUPAC Name:
- 6-aminonaphthalene-1,3-disulfonic acid
- Test material form:
- solid
- Details on test material:
- - Name of test material : 6-aminonaphthalene-1, 3-disulfonic acid
- Molecular formula : C10H9NO6S2
- Molecular weight : 303.314 g/mol
- Smiles notation : c12c(cc(S (=O)=O)cc1S (=O)=O )cc cc2
- Substance type: Organic
- Physical state: Solid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material : 6-aminonaphthalene-1, 3-disulfonic acid
- Molecular formula : C10H9NO6S2
- Molecular weight : 303.314 g/mol
- Smiles notation : c12c(cc(S (=O)=O)cc1S (=O)=O )cc cc2
- Substance type: Organic
- Physical state: Solid
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- no data available
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 750 µg
- Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- 24 hours
- Duration of post- treatment incubation (in vitro):
- no data available
- Number of animals or in vitro replicates:
- no data available
- Details on study design:
- no data available
Results and discussion
In vitro
- Other effects / acceptance of results:
- no data available
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Reversibility:
- not specified
- Remarks on result:
- probability of severe irritation
- Irritant / corrosive response data:
- severe irritation was observed
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- 6-amino-1,3- Naphthalene disulfonic acid (CAS No: 118-33-2) was severely irritating to rabbit eyes after 24 hours of exposure.
Hence, 6-amino-1,3- Naphthalene disulfonic acid (CAS No: 118-33-2) can be considered to be an eye irritant. - Executive summary:
The eye irritation potential of 6-amino-1,3- Naphthalene disulfonic acid (CAS No: 118-33-2) was assessed in rabbits.
750 µg of 6-amino-1,3- Naphthalene disulfonic acid was instilled into rabbit eyes and observed for signs of irritation till 24 hours.
6-amino-1,3- Naphthalene disulfonic acid was severely irritating to rabbit eyes after 24 hours of exposure.
Hence, 6-amino-1,3- Naphthalene disulfonic acid (CAS No: 118-33-2) can be considered to be an eye irritant.
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