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Diss Factsheets
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EC number: 232-178-2 | CAS number: 7789-60-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin Irritation:
The in vivo study need not be conducted because the substance is a strong acid (pH<=2.0) or strong base (pH=> 11.5).
The experimental pH of Phosphorus tribromide was 1.0
Hence this endpoint was considered for waiver.
According to in vitro study,it was concluded that test chemical was considered to be corrosive to human skin. Comparing the above annotations with the criteria of CLP regulation, it can be classified under the category “ Category 1''.
Eye Irritation:
The study need not be conducted because the substance is a strong acid (pH<=2.0) or strong base (pH=> 11.5).
The experimental pH of Phosphorus tribromide was 1.0
Hence this endpoint was considered for waiver.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study need not be conducted because the substance is a strong acid (pH <= 2.0) or base (pH => 11.5)
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study need not be conducted because the substance is a strong acid (pH <= 2.0) or base (pH => 11.5)
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin Irritation:
In different studies, the test chemical has been investigated for potential for dermal irritation to a greater or lesser extent. The studies are based on in- vitro and in-vivo experimental conductedin human and rabbits which have been summarized as below:
The in vivo study need not be conducted because the substance is a strong acid (pH<=2.0) or strong base (pH=> 11.5).
The experimental pH of Phosphorus tribromide was 1.0
Hence this endpoint was considered for waiver.
In the in vitro experimental study report,the dermal irritation potential of test article was determined according to the OECD 439 test guideline for this study. The MatTek EpiDerm™ model was used to assess the potential dermal irritation of the test article by determining the viability of the tissues following exposure to the test article via MTT. Tissues were exposed to the test article and controls for ~one hour, followed by a 42 hour post-exposure recovery period. The viability of each tissue was determined by MTT assay.The MTT data show the assay quality controls were met and passed the acceptance of criteria.The mean of OD for test chemical was determined to be 0.057 and 0.089 for 3 min. enpoint and 1 hour endpoint,respectively. The Mean % tissue viability compared to negative control (n=3) of the test chemical was determined to be 2.4% and 4.5% for 3 min. enpoint and 1 hour endpoint,respectively.Hence, under the current experimental test conditions it was concluded that test chemical was considered to be corrosive to human skin.
All these studies lead to a conclusion that Test chemical is indeed corrosive to skin. Hence, comparing the above annotations with the criteria of CLP regulation, Test chemical can be classified under the category “ Category 1”.
Eye Irritation:
The study need not be conducted because the substance is a strong acid (pH<=2.0) or strong base (pH=> 11.5).
The experimental pH of Phosphorus tribromide was 1.0
Hence this endpoint was considered for waiver.
Justification for classification or non-classification
According to the CLP Regulation (EC n. 1272/2008) and based on the low pH of Phosphorous tribromide, 1% w/v solution (pH= 1.00), the classification H314 (Causes severe skin burns and eye damage) is proposed for Phosphorous tribromide.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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