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EC number: 232-178-2 | CAS number: 7789-60-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- according to guideline
- Guideline:
- other: refer below principle
- Principles of method if other than guideline:
- Acute aquatic toxicity determine of test substance Phosphorus tribromide (PBr3) for 96 hrs exposure period.
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Phosphorus tribromide
- Molecular formula: Br3P
- Molecular weight: 270.686 g/mol
- Smiles notation: P(Br)(Br)Br
- InChl : 1S/Br3P/c14(2)3
- Substance type: Inorganic
- Physical state: Liquid - Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- Pimephales promelas
- Details on test organisms:
- TEST ORGANISM
- Common name:fathead minnows - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- 88 mg/L hardness as CaC03
- Test temperature:
- 22 ±2 °C
- Nominal and measured concentrations:
- 0.0, 6.25, 12.5, 25.0, 50.0 or 100.0 mg/L
- Details on test conditions:
- - No. of organisms per vessel:10 per group
- The static tests were performed in replicate and the results were pooled. - Reference substance (positive control):
- not specified
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 71 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 50 -100 mg/L confidence limit
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 25 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Validity criteria fulfilled:
- not specified
- Conclusions:
- In acute fish toxicity study the 96-hour LC50 value for fathead minnow was 71 mg/L (50 -100 mg/L confidence limit) and the no observed effect concentration (NOEC) was 25 mg/L was observed.
- Executive summary:
In Acute aquatic toxicity tests on fathead minnows(Pimephales promelas)Fathead minnows (10 per group) were exposed to 0.0, 6.25, 12.5, 25.0, 50.0 or 100.0 mg/L PBr3 in fresh water (88 mg/L hardness as CaC03) at 22 ±2 °C. The static tests were performed in replicate and the results were pooled. The 96-hour LC50 value for fathead minnow was 71 mg/L (50 -100 mg/L confidence limit) and the no observed effect concentration (NOEC) was 25 mg/L.
Based on the lethal concentration (LC50) value the Phosphorus tribromide was considered to be toxic to fish and can be considered to be classified in aquatic chronic 3 category a per the CLP regulations.
Reference
Description of key information
In Acute aquatic toxicity tests on fathead minnows(Pimephales promelas)Fathead minnows (10 per group) were exposed to 0.0, 6.25, 12.5, 25.0, 50.0 or 100.0 mg/L PBr3 in fresh water (88 mg/L hardness as CaC03) at 22 ±2 °C. The static tests were performed in replicate and the results were pooled. The 96-hour LC50 value for fathead minnow was 71 mg/L (50 -100 mg/L confidence limit) and the no observed effect concentration (NOEC) was 25 mg/L.
Based on the lethal concentration (LC50) value the Phosphorus tribromide was considered to be toxic to fish and can be considered to be classified in aquatic chronic 3 category a per the CLP regulations.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 71 mg/L
Additional information
Two studies including experimental data from reliable data source of short term fish toxicity endpoint for Phosphorus tribromide (7789-60-8) with relevant read across chemical which is structurally similar to target were summarized as follows:
First study from NTRL report, Human Effectiveness Directorate Deployment and Sustainment Division Operational Toxicology Branch, UNITED STATES AIR FORCE RESEARCH LABORATORY, 1997 and HSDB authorative database indicate that acute aquatic toxicity tests were conducted on fathead minnows (Pimephales promelas). Fathead minnows (10 per group) were exposed to 0.0, 6.25, 12.5, 25.0, 50.0 or 100.0 mg/L PBr3 in fresh water (88 mg/L hardness as CaC03) at 22 ±2 °C. The static tests were performed in replicate and the results were pooled. The 96-hour LC50 value for fathead minnow was 71 mg/L (50 -100 mg/L confidence limit) and the no observed effect concentration (NOEC) was 25 mg/L.
Based on the lethal concentration (LC50) value the Phosphorus tribromide was considered to be toxic to fish and can be considered to be classified in aquatic chronic 3 category a per the CLP regulations.
Above aquatic classification of target chemical supported by read across chemical Phosphorus trichloride (Cas no. 7719-12-2) study from authorative database (HSDB by US EPA; 2017) which indicate in short term fish toxicity the lethal concentration (LC100) was observed to be 65 mg/l in fish species sturgeon (Acipenser), carp (Cyprinus carpio), perch (Percidae), Esox lucius (northern pike), and Leuciscus leuciscus (dace).The mentioned lethal concentration indicate that the test substance Phosphorus trichloride toxic to fish.
Based on the both studies concluded that the test chemical Phosphorus tribromide (7789-60-8) toxic to fish for short exposure period.
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