Poly[oxy(methyl-1,2-ethanediyl)], α-hydro-ω-hydroxy-, ether with 2-ethyl-2-(hydroxymethyl)-1,3-propanediol (3:1), 2-propenoate

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Not specified

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.8 (Partition Coefficient - HPLC Method)

Deviations:

no

GLP compliance:

not specified

Type of method:

HPLC method

Partition coefficient type:

octanol-water

Analytical method:

high-performance liquid chromatography

Key result

Type:

log Pow

Partition coefficient:

>= 3.993 - <= 5.241

Temp.:

25 °C

pH:

7.66

Remarks on result:

other: for all constituents present at >5%

Details on results:

The chromatogram of the test substance solution showed 5 major peaks and 5 minor peaks (cfr "Any other information on results incl. tables"). With the calibration function log K versus log Pow, the corresponding log Pow values were determined. As peaks 1, 3, 7, 9 and 10 showed a relative area <5%, they were considered as minor peaks. Although area is not necessarily correlated to absolute concentration when UV detection is used, it was assumed that the test substance consisted mainly of the peaks 2, 4, 6 and 8, indicating that the log Pow of the test substance was in the range between 3.993 - 5.241 (mean).

Table 1. Detailed results

Peak	Mean area (mAU*min)1	Rel. area %	Mean retention time (min)	Log Pow (+/- stand. dev.)
1	25.0647	4.15	6.117	3.893 ± 0.000
2	171.373	28.37	6.507	3.993± 0.000
3	21.317	3.53	8.223	4.361± 0.000
4	181.668	30.08	8.775	4.460± 0.000
5	47.022	7.79	10.958	4.790± 0.000
6	74.002	12.25	12.024	4.924± 0.000
7	6.173	1.02	13.758	5.116± 0.000
8	42.455	7.03	15.025	5.241± 0.000
9	17.735	2.94	16.627	5.382± 0.000
10	17.198	2.85	20.824	5.692± 0.000

1. mAU = milli absorbance units

Conclusions:

Under the study conditions, the partition coefficient (log Pow) of the constituents present at >5% was determined to be in the range 3.993 - 5.241 at 25.0°C (HPLC method).

Executive summary:

A study was conducted to determine the partition coefficient of the test substance according to OECD guideline 117 and EU Method A.8 (HPLC method). A solution of the test substance was prepared by weighing 10.4 mg test substance into a 10 mL flask and filling up to 10.4 mL with the mobile phase. The measured pH of the test substance solution was 7.66 (measured with pH-Meter). This solution was also used for pre-test and for determination of the log Pow of the test substance. The chromatogram of the test substance solution showed 5 major peaks and 5 minor peaks. Capacity factor K and the retention times of the peaks of the test substance were used for for calculation of log Pow. Under the study conditions, the partition coefficient (log Pow) of the constituents present at >5% (corresponding to major peaks) was determined to be in the range 3.993 - 5.241 at 25.0°C (HPLC method) (Brinkmann, 2017).

Description of key information

The partition coefficient was determined according to OECD guideline 117 and EU Method A.8 (HPLC method) (Brinkmann, date not specified)

Key value for chemical safety assessment

Log Kow (Log Pow):

5.24

at the temperature of:

25 °C

Additional information

Ranges from 3.99 - 5.24 (for all constituents present at >5%)