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Diss Factsheets
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EC number: 215-223-0 | CAS number: 1314-15-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
According to a brief summary in an Expert Group report (DECOS, 2008) of a 40-year-old study, male Sprague-Dawley rats received platinum(IV) oxide in the diet at a level corresponding to a dose of about 815 mg/kg bw/day for 4 weeks. No effect on growth was apparent (Holbrook, 1976; Holbrook et al., 1976). Marginal effects on a small number of clinical chemistry parameters [likely including aniline hydroxylase and cytochrome b5 activity] were noted following such treatment (Holbrook et al., 1976).
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
According to a brief summary in an Expert Group report (DECOS, 2008) of a 40-year-old study, male Sprague-Dawley rats received platinum(IV) oxide in the diet at a level corresponding to a dose of about 815 mg/kg bw/day for 4 weeks. No effect on growth was apparent (Holbrook, 1976; Holbrook et al., 1976). Marginal effects on a small number of clinical chemistry parameters [likely including aniline hydroxylase and cytochrome b5 activity] were noted following such treatment (Holbrook et al., 1976).
References (not included elsewhere in this IUCLID dossier)
DECOS (2008). Dutch Expert Committee on Occupational Standards. Platinum and Platinum Compounds. Health-based recommended occupational exposure limit. Gezondheidsraad, 2008/12OSH.https://www.gezondheidsraad.nl/en/publications/gezonde-arbeidsomstandigheden/platinum-and-platinum-compounds-health-based-recommended
Holbrook DJ (1976). Assessment of toxicity of automotive metallic emissions. vol 1: Assessment of fuel additives emission toxicity via selected assays of nucleic and protein synthesis, Research Triangle Park, North Carolina, US Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratories, 67 pp (EPA/600/1-76/010a) [cited in DECOS, 2008].
Holbrook DJ et al. (1976). Effects of platinum and palladium salts on parameters of drug metabolism in rat liver. J Toxicol Environ Health 1:1067-1079 [cited in DECOS, 2008].
Justification for classification or non-classification
No evidence of specific target organ toxicity was noted in the limited repeated dose studies identified. As such, classification for STOT-RE is not considered appropriate.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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