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EC number: 215-223-0 | CAS number: 1314-15-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- not stated
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study, to GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Platinum dioxide
- EC Number:
- 215-223-0
- EC Name:
- Platinum dioxide
- Cas Number:
- 1314-15-4
- Molecular formula:
- O2Pt
- IUPAC Name:
- Platinum dioxide
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): Platinum (IV) oxide Type D
- Substance type:
- Physical state: powder
- Analytical purity: not stated
- Impurities (identity and concentrations):
- Composition of test material, percentage of components:
- Isomers composition:
- Purity test date:
- Lot/batch No.: CC0198
- Expiration date of the lot/batch:
- Radiochemical purity (if radiolabelling):
- Specific activity (if radiolabelling):
- Locations of the label (if radiolabelling):
- Expiration date of radiochemical substance (if radiolabelling):
- Stability under test conditions:
- Storage condition of test material: grey plastic tub; room temperature
- Other:
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: David percival Ltd., Moston, Sandbach, Cheshire, U.K.
- Age at study initiation: 12 - 16 weeks
- Weight at study initiation: 2.75 - 3.29 kg
- Housing: individually housed in suspended metal cages
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18 - 21
- Humidity (%): 48 - 58
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12 / 12
IN-LIFE DATES: From: To:
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: left eye untreated and served as control
- Amount / concentration applied:
- 100 mg/eye
- Duration of treatment / exposure:
- Test material placed into conjunctival sac of the right eye, formed by gently pulling the lower lid away from the eyball. Upper and lower eyelids were held together for about one second immediately after application and then released. Test material was not washed out.
- Observation period (in vivo):
- Grading timepoints: 1, 24, 48 and 72 hours
Reversibility assessed at 7 days - Number of animals or in vitro replicates:
- One animal treated initially. After consideration of ocular response, two additional animals were treated.
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): no
- Time after start of exposure: not applicable
SCORING SYSTEM:
Quantitative, using Draize scale (cornea: degree of opacity 0-4, area affected 1-4; iris 0-2; conjunctiva: redness 0-3, chemosis 0-4, discharge 0-3).
Interpretation using modified Kay and Calandra scheme (0-8 point irritation scale)
TOOL USED TO ASSESS SCORE: light source from standard ophthalmoscope
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0.7
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0.7
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0.3
- Max. score:
- 2
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0.3
- Max. score:
- 2
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal #1
- Time point:
- other: 24, 48, 72 hours
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal #2
- Time point:
- other: 24, 48, 72 hours
- Score:
- 1.7
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 72 hours
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal #3
- Time point:
- other: 24, 48, 72 hours
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- other: 24, 48, 72 hours
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- other: 24, 48, 72 hours
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Irritant / corrosive response data:
- Corrosive:No
Irritation Score: Cornea/Iris:
Cornea: at 24 and 48 hours - diffuse corneal opacity in 2/3 eyes (degree 1, area 1); no other corneal effects.
Iris: at 1 hour - iridial inflammation (1) in 3/3 eyes; 24 hours - iridial inflammation (1) in 2/3 eyes; no other iridial effects.
Irritation Score: Conjunctivae (Redness/Chemosis):
Conjunctivae: at 1 hour - moderate conjunctival irritation in 3/3 eyes (redness 2, chemosis 2, discharge 2); at 24 hours - minimal to moderate conjunctival irritation in 3/3 eyes (redness 2, chemosis 1-2, discharge 0-3); at 48 hours - minimal conjunctival irritation in 3/3 eyes (redness 1-2, chemosis 0-1, discharge 0); at 72 hours - minimal conjunctival irritation in 1/3 eyes (redness 1, chemosis 0, discharge 0); no other conjunctival effects.
Overall Irritation Score:
Highest overall irritation score 17.0, with group mean score at 72 hours >0; Kay and Callandra class 5, moderate irritant
Any other information on results incl. tables
3/3 animals affected.
Scores were reduced over time.
Effects were reversible.
Residual test material was found around the treated eye.
For Kay and Callandra classification, group mean scores (3 animals) for each timepoint:
1 hour - 17.0 (individual scores 17, 17, 17)
24 hours - 16.7 (individual scores 6, 24, 20)
48 hours - 7.3 (individual scores 2, 11, 9)
72 hours - 0.7 (individual scores 0, 2, 0)
7 days - 0 (1 animal)
Highest overall irritation score 17.0, with group mean score at 72 hours >0, placing the test material in class 5, moderate irritant.
For EC classification, mean scores (24, 48 and 72 hours) for individual animals:
Corneal opacity - 0.0, 0.7, 0.7
Iridial inflammation - 0.0, 0.3, 0.3
Conjunctival redness - 1.0, 1.7, 1.0
Conjunctival chemosis - 0.3, 1.0, 1.0
Test material does not meet the limits required by the EC regulation for hazard labelling.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Conclusions:
- In a guideline study, to GLP, instillation of platinum dioxide (0.1 g) produced moderate irritation in three rabbits after a 72-hr observation period. The substance would not be classified under EU CLP criteria.
- Executive summary:
In an OECD Test Guideline 405 study, conducted to GLP, the potential of platinum dioxide to cause eye irritation was assessed in rabbits. The test material (0.1 g) was instilled into the conjunctival sac of the right eye of each of three New Zealand White rabbits, without irrigation. Diffuse corneal opacity, iridial inflammation and moderate conjunctival irritation were observed during the 72-hr observation period; only conjunctival redness had not reversed during this period (though it had lessened in severity). The test material produced a maximum group mean score of 17.0 and was classified as a moderate irritant (Class 5 on a 1 to 8 scale) to the rabbit eye according to a modified Kay and Calandra classification system. However, no classification for eye irritation is required based on EU CLP criteria (EC 1272/2008).
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