Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 407-410-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1990-11-27 to 1990-12-04
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study. An updated OECD guideline 405 from 2012 is available; changes do not affect the reliability of this study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- (1981)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Version / remarks:
- 84/449/EEC
- GLP compliance:
- yes
Test material
- Reference substance name:
- 4,7-methanooctahydro-1H-indene-diyldimethyl bis(2-carboxybenzoate)
- EC Number:
- 407-410-2
- EC Name:
- 4,7-methanooctahydro-1H-indene-diyldimethyl bis(2-carboxybenzoate)
- Molecular formula:
- C28H40O8
- IUPAC Name:
- 2-[({5-[(2-carboxycyclohexanecarbonyloxy)methyl]tricyclo[5.2.1.0²,⁶]decan-8-yl}methoxy)carbonyl]cyclohexane-1-carboxylic acid; 2-[({8-[(2-carboxycyclohexanecarbonyloxy)methyl]tricyclo[5.2.1.0²,⁶]decan-4-yl}methoxy)carbonyl]cyclohexane-1-carboxylic acid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): TCD-Emulgator
- Substance type: White solid
- Physical state: Solid
- Purity test date: 1990-04-26
- Lot/batch No.: 90003
- Expiration date of the lot/batch: 1992-01-08
- Storage condition of test material: At room temperature and in darkness
- pH: 5.0 (1 % in H2O)
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Interfauna U.K. Ltd., Wyton, Huntingdon, England
- Age at study initiation:
- Weight at study initiation: 3.5, 3.2, and 3.6 kg, all female
- Housing: Individually in stainless steel cages
- Diet (e.g. ad libitum): Standard diet "Ssniff K 4", approx. 100-120 g per animal and day (fed in the morning)
- Water (e.g. ad libitum): Tap water, ad libitum
- Acclimation period: 14 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 ± 3 °C
- Humidity (%): Approx. 50 %
- Air changes (per hr): Approx. 10/h
- Photoperiod (hrs dark / hrs light): 12/12 (illumination from 6 to 18 hrs CET)
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 100 µl (approx. 40 mg) - Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- 7 d
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): Rinsing with saline
- Time after start of exposure: 24 h
SCORING SYSTEM: Draize Grades
TOOL USED TO ASSESS SCORE: Hand-slit lamp, fluorescein
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 0.1
- Max. score:
- 0.3
- Reversibility:
- fully reversible
- Irritation parameter:
- conjunctivae score
- Remarks:
- Erythema
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 1.2
- Max. score:
- 1.3
- Reversibility:
- fully reversible
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 0.1
- Max. score:
- 0.3
- Reversibility:
- fully reversible
Any other information on results incl. tables
Results for the grading of irritating effects on the eye:
Animal no./ Sex |
Body weight |
Tissue |
Signs |
DRAIZE grades |
Irritation index |
||||||
1 h |
24 h |
48 h |
72 h |
7 d |
14 d |
21 d |
|||||
M26/ Female |
2.7 kg |
Cornea |
o |
0 |
0 |
0 |
0 |
0 |
- |
- |
0.0 |
a |
0 |
0 |
0 |
0 |
0 |
- |
- |
|
|||
Fluorescein |
i |
- |
1 |
1 |
0 |
- |
- |
- |
|
||
a |
- |
1c |
1p |
0 |
- |
- |
- |
|
|||
Iris |
|
0 |
0 |
0 |
0 |
0 |
- |
- |
0.0 |
||
Conjunctivae |
r |
1 |
1 |
1 |
1 |
0 |
|
|
1.0 |
||
s |
1 |
0 |
0 |
0 |
0 |
|
|
0.0 |
|||
Aqueous humour |
|
0 |
0 |
0 |
0 |
0 |
- |
- |
|
||
Discharge |
|
1 |
0 |
0 |
0 |
0 |
- |
- |
|
||
M25/ Female |
2.9 kg |
Cornea |
o |
0 |
0 |
0 |
0 |
0 |
- |
- |
0.0 |
a |
0 |
0 |
0 |
0 |
0 |
- |
- |
|
|||
Fluorescein |
i |
- |
1 |
1 |
0 |
- |
- |
- |
|
||
a |
- |
2c |
1c |
0 |
- |
- |
- |
|
|||
Iris |
|
0 |
1 |
0 |
0 |
0 |
- |
- |
0.3 |
||
Conjunctivae |
r |
1 |
2 |
1 |
1 |
0 |
- |
- |
1.3 |
||
s |
2 |
1 |
0 |
0 |
0 |
|
|
0.3 |
|||
Aqueous humour |
|
0 |
0 |
0 |
0 |
0 |
- |
- |
|
||
Discharge |
|
3 |
0 |
0 |
0 |
0 |
- |
- |
|
||
K8/ Female |
3.4 kg |
Cornea |
o |
0 |
0 |
0 |
0 |
0 |
- |
- |
0.0 |
a |
0 |
0 |
0 |
0 |
0 |
- |
- |
|
|||
Fluorescein |
i |
- |
0 |
- |
- |
- |
- |
- |
|
||
a |
- |
0 |
- |
- |
- |
- |
- |
|
|||
Iris |
|
0 |
0 |
0 |
0 |
0 |
- |
- |
0.0 |
||
Conjunctivae |
r |
1 |
2 |
1 |
1 |
0 |
- |
- |
1.3 |
||
s |
1 |
0 |
0 |
0 |
0 |
|
|
0.0 |
|||
Aqueous humour |
|
0 |
0 |
0 |
0 |
0 |
- |
- |
|
||
Discharge |
|
1 |
0 |
0 |
0 |
0 |
- |
- |
|
o: Opacity
a: Area
i: Intensity
r: Redness
s: Swelling
-: Not examined
c: Confluent diffuse areas
p: Scattered punctate
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The eye irritant/corrosive potential of the test item was assessed in rabbits according to OECD guideline 405 and EU method B.5. The test substance induced slight reactions of the mucous membranes and mild corneal effects which were fully reversible within 7 days. The substance is regarded as slightly irritating.
- Executive summary:
In a primary eye irritation study in accordance with OECD guideline 405 and EU method B.5, 100 µl of TCD-emulsifier was instilled into the conjunctival sac of adult rabbits (strain: HC:NZW) (3 female) for 24 hours. The eyes were rinsed with saline after 24 h of exposure. Animals then were observed for 7 days. Irritation was scored by the method of DRAIZE.
The exposure induced slight reactions of the mucous membranes and mild corneal effects which were fully reversible within 7 days. Based on the study results, the test item is not classified as an eye irritant according to CLP Annex I.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.