Registration Dossier
Registration Dossier
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EC number: 202-869-3 | CAS number: 100-60-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1961
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: non GLP, substance clearly identified as corrosive. Sufficient details reported.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 961
- Report date:
- 1961
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- 15 min exposure regime
- GLP compliance:
- no
Test material
- Details on test material:
- Name of the test substance used in the study report: N-Monomethylcyclohexylamin
physical state: liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin of the same animal
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- 15 min
- Observation period:
- 8 days resp. 5 weeks
- Number of animals:
- 2
- Details on study design:
- Application area: 2.5 x 2.5 cm2
Results and discussion
Any other information on results incl. tables
Observations after 24 hours and 8 days: The 15-min application of the test substance showed a black-red severe necrosis. After 5 weeks, bloody scars were noted.
Applicant's summary and conclusion
- Interpretation of results:
- highly corrosive
- Remarks:
- Migrated information
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