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Diss Factsheets
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EC number: 202-869-3 | CAS number: 100-60-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: non GLP, but reported in detail and procedure comparable to OECD guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- Body weight after 14 days not reported; less details on housing conditions and test item.
- GLP compliance:
- no
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Details on test material:
- Name of the test substance used in the study report: N-Monomethylcyclohexylamin
physical state: liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Mean body weights for male animals: 218 g, mean body weights for female animals: 180 g
A standardized animal laboratory diet as well as drinking water were available ad libitum.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- The test substance was applied in concentrations of 50% (400 mg/kg) and 100% (1000 mg/kg).
The product was applied to the clipped skin of the back and flank (area about 50 cm2) unchanged in a dose of 1000 mg/kg and as a 50% aqueous formulation in a dose of 400 mg/kg.
The hair was removed from the dorsal and lateral parts of the trunk using electric clippers about 15 to 24 hours before the application. Only animals with healthy and intact skin were used for the study.
The test substance or the formulation of the test substance was applied uniformly to an area of about 50 cm2. The treated area of skin was then covered with an inert foil, which was secured in position with adhesive tape. The bandage was removed after a 24-hour period of contact; subsequently the compound was washed off with warm water and dried with cellulose. - Duration of exposure:
- 24 h
- Doses:
- 400, 1000 mg/kg
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- Examinations:
Mortality within 14 days
Signs of systemic toxicity and local changes
Necropsy of the animals that died intercurrently and of those sacrificed by carbon dioxide at the end of the observation period.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 400 - < 1 000 mg/kg bw
- Mortality:
- 400 mg/kg: no deaths after 14 days
1000 mg/kg: 5/6 after 14 days
(see table 1) - Clinical signs:
- Signs af systemic toxicity: Dyspnea, apathy, excitatian, staggering, atony, trembling, poor general state.
Local changes: 24 hours after application severe soft necrosis, slight till severe edema; after 7 days severe parchmeng-like necrosis, partly sallied; after 13 days severe leather-like necrosis, partly sallied. - Gross pathology:
- Animals that died: acute congestive hyperemia; heart: acute dilatation of the atrium; lung: slightly edematous, acute middle-graded pulmonary emphysema; liver: peripheral lobule delineation.
Sacrificed animals: nothing abnormal detected.
Any other information on results incl. tables
Table 1: Onset and incidence of mortality
number of animals found dead | |||||||
Dose | gender | total number in dose group | 1h | 24h | 48h | 7 days | 14 days |
1000 mg/kg bw | males | 3 | 0 | 0 | 0 | 2 | 2 |
1000 mg/kg bw | female | 3 | 0 | 1 | 3 | 3 | 3 |
400 mg/kg bw | males | 3 | 0 | 0 | 0 | 0 | 0 |
400 mg/kg bw | females | 3 | 0 | 0 | 0 | 0 | 0 |
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LC50 (rat, dermal) is between 400 and 1000 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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