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EC number: 203-661-5 | CAS number: 109-28-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
A toxicity study on aquatic algae with N-[3-(Dimethyl lamino)propyl]oleamide is not available. Consequently, read-across was applied using a characteristically similar compound (CAS# 84082-43-9; Amides, C8-22, N-[3-(dimethylamino)propyl)]. The chronic toxicity of the test item to fresh-water green algae Pseudokirchneriella subcapitata was determined according to the method C.3 of the Directive 92/69/EEC of the European Commission, which is in conformity with the OECD Guideline 201. The results showed an EC50 value of 0.003 mg/L based on cell growth and 0.005 mg/L based on growth rate. The NOEC was 0.002 and 0.003 mg/L based on cell growth and growth rate, respectively. The very low EC50 value may be related to a true algicidal effect of the test item.
Key value for chemical safety assessment
Additional information
The chronic toxicity of the test item to
fresh-water green algae Pseudokirchneriella subcapitata was determined
according to the method C.3 of the Directive 92/69/EEC of the European
Commission, which is in conformity with the OECD Guideline 201.
Algae were exposed to a range of concentrations of the test item
dissolved in dilution water. The toxic effect measured during the assay
was the inhibition of cellular multiplication over a time period of 72
hours. The cell density was measured daily. Analytical chemistry and
physico-chemical measurements were carried out at the beginning and the
end of the test. The concentration and loading of test item causing a
50% reduction in biomass (EbC50 and EbL50) or in growth rate (ErC50 and
ErL50) were determined. The EC50 and NOEC values are derived from the
analytical measurements. EL50 -72 hours derived from loading rate of the
WAF are also reported.
The results were as follows:
Effective concentrations and loading [mg/L] |
||
|
Value |
95% Cl |
Cell growth (biomass) |
||
EbC50 (72 h) |
0.003 |
ND |
NOECb |
0.002 |
- |
EbL50 (72 h) |
0.022 |
ND |
Growth rate |
||
ErC50 (72 h) |
0.005 |
ND |
NOECr |
0.003 |
- |
ErL50 (72 h) |
0.03 |
ND |
Effective concentrations and NOEC shown in
the previous table have been calculated using the geometric average
values between initial and final concentrations of the test substance.
Concentration were measured by liquid chromatography coupled with mass
spectrometry. Initial and final concentrations were not equivalent to
nominal concentrations.
The validity criterion of the study related to the growth of algae was
fulfilled: the increase in the cell density (R), measured in the control
solution between the end and the beginning of the test, was greater than
a factor of 16 (R = 66). The validity criterion specific to C3 92/69 EEC
method and related to the test item stability during the test was not
respected: the final concentrations of the test item were not maintained
within the designated limit of 80% of the initial concentrations.
As already discussed for the adsorption / desorption study: The test
substance tends to adsorb to the glass container. In general, fatty
amines have a very high adsorption to glass surfaces due to its cationic
nature. This effect is most noticeable at lower concentrations.
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