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EC number: 700-903-6 | CAS number: 255830-15-0
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted in accordance with OECD 111 but full details are not available.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Radiolabelling:
- not specified
- Buffers:
- - pH: 4 and 7
- Composition of buffer: potassium Bi-phthalate/NaOH
- pH: 9
- Composition of buffer: Borate mixture - Duration:
- 20 d
- Transformation products:
- yes
- Remarks:
- measured as inorganic phosphorus
- No.:
- #1
- pH:
- 4
- Temp.:
- 20 °C
- Remarks on result:
- other: 0% hydrolysed
- pH:
- 4
- Temp.:
- 40 °C
- Remarks on result:
- other: 10% hydrolysed
- pH:
- 4
- Temp.:
- 70 °C
- Remarks on result:
- other: 100% hydrolysed
- pH:
- 7
- Temp.:
- 20 °C
- Remarks on result:
- other: at 20°C, 40°C and 70°C, 0% hydrolysed
- pH:
- 9
- Temp.:
- 20 °C
- Remarks on result:
- other: at 20°C and at 40°C, 0% hydrolysed
- pH:
- 9
- Temp.:
- 70 °C
- Remarks on result:
- other: 100% hydrolysed
- Details on results:
- The test substance was found to be stable at pH 7 and at 20°C, 40°C and 70°C. However, at pH 4 and pH 9 and 70°C, fast hydrolysis was observed.
- Conclusions:
- The substance was found to be stable to hydrolysis at pH 7 and 20°C, 40°C and 70°C. At pH 4 and pH 9 and 70°C, fast hydrolysis was observed.
Reference
Results:
|
|
Inorganic weight (mg/100 ml) |
||||
Sample amount (g/ 100 ml) |
pH/T |
Time 0 |
3 days |
6 days |
15 days |
20 days |
5.623 |
4/20 4/40 4/70 |
39.3 38.9 39.1
|
38.9 39.0 265.0 |
39.1 39.0 394.0 |
38.9 45.0 410.0 |
39.0 80.1 420.7 |
5.155 |
7/20 7/40 7/70 |
36.0 35.9 36.2 |
35.9 36.0 38.0 |
36.0 38.1 38.2 |
36.1 48.5 38.1 |
36.0 37.8 39.1 |
5.263 |
9/20 9/40 9/70 |
36.9 36.9 36.8 |
36.5 37.0 37.2
|
36.8 36.8 37.5 |
37.0 33.9 399.0 |
36.8 36.8 401.0 |
Table 2:
Percent hydrolysed |
|||||||||
T/pH |
4 |
7 |
9 |
||||||
|
Number of days |
||||||||
|
0 |
6 |
20 |
0 |
6 |
20 |
0 |
6 |
20 |
20±1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
40±1 |
0 |
0 |
10 |
0 |
0 |
0 |
0 |
0 |
0 |
70±1 |
0 |
90.2 |
100 |
0 |
0 |
0 |
0 |
0 |
100 |
Description of key information
ATMP-N-oxide-5K is not hydrolytically unstable under ambient conditions.
Key value for chemical safety assessment
Additional information
A reliable study is available, conducted in accordance to OECD 111, the substance was found to be stable to hydrolysis at pH 7 at ambient and elevated temperatures (40°C and 70°C).
At pH 4 and pH 9 and 70°C, fast hydrolysis was observed. Similarly, in a secondary source, the parent acid of the salt (ATMP-N-oxide) was determined to have a hydrolysis half-life of >650 hr, >2000 hr and >>2000 hr at pH 2, 6 and 10 and 25°C respectively, full details on the methods are not available and the reliability could not be assigned. It could however be extrapolated that the substance is hydrolytically stable.
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