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EC number: 203-786-5 | CAS number: 110-63-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- GLP compliance:
- no
- Analytical monitoring:
- no
- Test organisms (species):
- activated sludge, industrial
- Details on inoculum:
- - Laboratory culture: activated sludge from industrial waste water treatment plant
- Initial biomass concentration: approx. 1 g/L - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 30 min
- Hardness:
- not specified
- Test temperature:
- not specified
- pH:
- not specified
- Dissolved oxygen:
- not specified
- Salinity:
- not specified
- Conductivity:
- not specified
- Nominal and measured concentrations:
- not specified
- Details on test conditions:
- not specified
- Reference substance (positive control):
- not specified
- Key result
- Duration:
- 30 min
- Dose descriptor:
- other: EC20
- Effect conc.:
- > 788 mg/L
- Endpoint:
- toxicity to microorganisms, other
- Remarks:
- Growth impairment test with the freshwater ciliate Tetrahymena pyriformis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Growth impairment of the freshwater ciliate Tetrahymena pyriformis according to methods described by Shultz, T.W. Toxicol. Methods 7: 289-309.
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- not specified
- Details on test solutions:
- not specified
- Test organisms (species):
- Tetrahymena pyriformis
- Details on inoculum:
- not applicable
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 40 h
- Post exposure observation period:
- not specified
- Hardness:
- not specified
- Test temperature:
- not specified
- pH:
- not specified
- Dissolved oxygen:
- not specified
- Salinity:
- not specified
- Conductivity:
- not specified
- Nominal and measured concentrations:
- not specified
- Details on test conditions:
- The endpoint, population density, of this static 40-h assay was measured spectrophotometrically at 540 nm. Test conditions allow for 8-10 cell cycles in control cultures. The chemical was tested in a range finder prior to testing in duplicate for three additional replicates. Two controls, one without test chemical but inoculated with T. pyriformis, and the other, a blank with neither test substance nor ciliates, were used to provide a measure of the test acceptability. Each definitive test replicate consisted of six to eight different concentrations with duplicate of each concentration. Only replicates with control-absorbency values between 0.6 and 0.75 were used in the analyses. The 50 % growth inhibition concentration (IGC50) was determined by Probit Analysis (SAS software).
- Key result
- Duration:
- 40 h
- Dose descriptor:
- other: IGC50
- Effect conc.:
- 15 536.6 - 15 786.28 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (total fraction)
- Basis for effect:
- growth inhibition
Referenceopen allclose all
- No inhibition at 400 mg/l DOC, but promotion of respiration at 400 mg/L DOC:
108 %
- 2.590 mg/l DOC = 507.8 mg DOC/g TS: from this follows that EC20 > 788 mg/l.
Original toxicity value of the narcotic 1,4-butanediol IGC50 (40 h) = 15786.28 mg/L (12218-20414 mg/L).
Re-tested toxicity value of the narcotic 1,4-butanediol: IGC50 (40 h) = 15536.6 mg/L (11661-20408 mg/L).
Description of key information
Impairment of Growth Concentration 50% (IGC50) is based on a test with tetrahymena pyriformis.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 15 500 mg/L
Additional information
The toxicity of 1,4 -Butanediol to microorganisms has been tested under non-GLP conditions according to several guideline methods that examine respiration inhibition and growth inhibition. In addition, a number of ready biodegradation and inherent biodegradation tests have been performed which provide insight into the degree of toxicity to microorganisms. For studies having a Klimisch score of at least 2, the data are as follows: No toxicity was observed at 430 mg/L as part of an OECD 302 B inherent biodegradibility test (BASF, 1977), an EC20 of >788 mg/L was reported from an OECD 209 activated sludge respiration inhibition test (LGU, 1990), and an IGC50 of 15536 mg/L was reported in a ciliated growth inhibition test with tetrahmena pyroformis (Seward, J.R. et.al., 2001). Given these results, it can be concluded that 1,4 -Butanediol exhibits low toxicity to microorganisms.
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