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Diss Factsheets
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EC number: 227-006-8 | CAS number: 5593-70-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Testing is not scientifically justified as substance is hydrolytically unstable. Based on the rapid hydrolysis, and the ready biodegradability and low aquatic toxicity of the known decomposition products, this substance can be considered as readily degradable.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
Testing of biodegradability of titanium tetrabutanolate is not scientifically justified as it is hydrolytically unstable. When this substance comes in contact with water or moisture, a complete hydrolysis will take place with no significant reaction products other than n-butanol and hydrated titanium dioxides (half-life less than 5 minutes, OECD 111; Brekelmans 2013). In addition, biodegradability testing is not necessary as all the decomposition products have been identified. The most relevant degradation product (n-butanol) is also readily biodegradable. The other environmentally non-hazardous degradation product (TiO2) is inorganic and insoluble and therefore not relevant to be considered for this endpoint.
Several studies have been conducted to assess the biodegradation of n-butanol in water and treated sewage. Aerobic biodegradation in unadapted sludge was found to be 37 % of ThOD after 24 hours (Gerhold and Malaney 1966). Aerobic biodegradation in adapted sludge was measured to be 44 % of ThOD after 23 hours (McKinney and Jeris 1955). The 20-d biodegradation-% of n-butanol using settled domestic wastewater was 92 % in freshwater and 82 % in synthetic sea water at nominal test concentrations of 3, 7 and 10 mg/l (Price et al. 1974). Based on these studies n-butanol is readily biodegradable under aerobic conditions.
Based on the information on aquatic toxicity and biodegradation of the decomposition products, and the rapid hydrolysis of the target substance, the abiotic degradation can be used to demonstrate fast degradation of this substance for the purposes of C&L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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