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Diss Factsheets
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EC number: 227-006-8 | CAS number: 5593-70-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
Hydrolytically unstable as per OECD 111. The half-life time of the substance is <5 minutes at 25 deg. C at pH 4, 7 and pH 9.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 5 min
- at the temperature of:
- 25 °C
Additional information
Study was performed by using OECD 111 in accordance with GLP. However, as the substance is highly hydrolytically unstable it was not possible to perform the test as outlined in the guidelines. In order to obtain as much information on hydrolysis as possible, an alternative test was designed. The hydrolytic stability was tested in buffered aqueous solutions at pH 4.0, 7.0, and 9.0 at 25°C for 40 minutes. The progress of the hydrolysis was followed by monitoring the main degradation product; n-butanol. Additionally, the formation of a white precipitation was observed during the hydrolysis study. This is due to the formation of the insoluble titanium oxides. No other degradation products were identified.
The predicted hydrolysis product, n-butanol, was detected by GC-MS. Known hydrolysis products were identified based on retention time and mass of detection. The response of the hydrolysis product n-Butanol was > 99% (area). In the chromatograms, small additional peaks were observed at 2.20 – 2.51 minutes (at pH 4), 3.27 or 3.28 minutes, 4.03 minutes, 4.16 minutes, 4.44 minutes, 4.93 minutes (at pH 7 and pH 9) and 11.48 minutes (at pH 9), all < 1% at the specific mass fragments monitored.
The additional peaks might derive from impurities in the test substance and/or hydrolysis products. To achieve sufficient sensitivity for the analysis of the identified hydrolysis product, selected ion monitoring was used as detection method. Therefore it was not possible to obtain accurate information on the mass fraction of the unknown peaks or to record their entire mass spectrum, and hence it was not possible to identify these additional peaks.
Based on the results, it was concluded that the hydrolysis half-life time at 25 0C is < 5 minutes. The results of this study are considered reliable to be used for C&L purposes. Based on the results this substance can be considered as rapidly degradable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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