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Diss Factsheets
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EC number: 210-323-0 | CAS number: 612-83-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Epidemiological data
Administrative data
- Endpoint:
- epidemiological data
- Type of information:
- other: cancer incidence data collection
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented study report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
- Study type:
- cohort study (retrospective)
- Endpoint addressed:
- carcinogenicity
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- EPIDEMIOLOGICAL STUDY
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3,3'-dichlorobenzidine dihydrochloride
- EC Number:
- 210-323-0
- EC Name:
- 3,3'-dichlorobenzidine dihydrochloride
- Cas Number:
- 612-83-9
- Molecular formula:
- C12H10Cl2N2.2ClH
- IUPAC Name:
- 3,3'-dichloro-[1,1'-biphenyl]-4,4'-diamine dihydrochloride
Constituent 1
Method
- Type of population:
- occupational
- Ethical approval:
- not specified
- Details on study design:
- 99 persons (88 men and 11 women) who had worked with DCBDC for at least one year since 1947 were included into these examinations. From 1947 to 1993, clinical examinations were made once a year, with cytological examinations of the urine every six months on all persons exposed to DCB in the plant area and in the laboratories. The occurence of cancer in this group was compared with the figures expected for the normal population.
- Details on exposure:
- Over the years, a number of DCBDC measurements have been taken in relation to the working environment. From 1983 the Analytical Laboratory has taken measurements on airborne dust to analyze for DCBDC. Dust was collected on a filter (0.8 µm), which is then weighed. As not all dust is DCBDC, the filter is washed out and a chemical analysis made on DCBDC in the liquid.
Results and discussion
- Results:
- Among the 99 persons, 88 were men and 11 women. In the period from 1947 to 1990, there was a total of 6 cases of cancer among the men (5.19 were expected). Among the women there were no cases of cancer (0.23 expected).
Applicant's summary and conclusion
- Conclusions:
- On the basis of work published previously and this epidemiological study, it is concluded that DCBDC itself does not promote cancer in human beings under common working conditions.
- Executive summary:
Since DCBDC was introduced in the plant in Koge, there have been medical examinations of employees as well as urine cytology testing at least once a year. Furthermore, we have investigated through the Danish Cancer Society the incidence of cases of cancer among all employees at Sun Chemical A/S (KVK) exposed to DCBDC up to 1990. These investigations show that there seems to be no risk of cancer when working with DCBDC during pigment production. On the present showing, DCBDC in itself does not seem to have a carcinogenic effect on human beings.
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