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Diss Factsheets
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EC number: 202-808-0 | CAS number: 99-99-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Toxic hazards evaluation of five atmospheric pollutants from army ammunition plants.
- Author:
- Kinkead ER, MacEwen JD, Haun CC, Vernot EH
- Year:
- 1 977
- Bibliographic source:
- US AMBRD: TR 7703, NTIS ADA043957
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 977
- Reference Type:
- secondary source
- Title:
- 4-Nitrotoluene - CAS N°: 99-99-0 - SIDS Initial Assessment Report.
- Author:
- OECD
- Year:
- 2 003
- Bibliographic source:
- UNEP Publications
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- Analytical purity not reported. Animal housing conditions not reported. Only one dose concentration tested
- GLP compliance:
- no
- Remarks:
- GLP was not mandatory at the time of the study
- Test type:
- standard acute method
Test material
- Reference substance name:
- 4-nitrotoluene
- EC Number:
- 202-808-0
- EC Name:
- 4-nitrotoluene
- Cas Number:
- 99-99-0
- Molecular formula:
- C7H7NO2
- IUPAC Name:
- 1-methyl-4-nitrobenzene
- Details on test material:
- - Name of test material (as cited in study report): p-nitrotoluene
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Sprague-Dawley and CFE rats
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: air
- Details on inhalation exposure:
- p-nitrotoluene was tested by a static technique whereby an excess of the compound was sealed into a 120-liter plexiglass chamber for a period of 24 hours (the saturation conc. at 22 °C were calculated from Antoine equation). The experimental animals were then rapidly introduced into the chamber by means of a sliding cage drawer designed to minimize vapour loss. All exposures were continuously analyzed using a Beckman Model 400 total hydrocarbon analyzer.
- Duration of exposure:
- 4 h
- Concentrations:
- 152 ppm (67 % of saturation) = 851 mg/m³
- No. of animals per sex per dose:
- 10
- Control animals:
- other: not applicable
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: All animals were observed for sings of toxicity and mortality during exposure and for the 4-days immediately following exposure. Animals were weighed immediately prior to exposure and again at 14 days postexposure on survivors
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, grosspathology - Statistics:
- Determination of the LC50 was made by probit method (Finney, 1952, Probit Analysis, 2nd Edition, King Review Press)
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 851 mg/m³ air
- Exp. duration:
- 4 h
- Body weight:
- All animals gained weight normally during the 14-day observation period.
Any other information on results incl. tables
No death occurred during exposure or during the subsequent 14-d observation period. Gross pathologic examination of rats sacrificed after 14 days revealed no leasions which could be attributed to exposure (no further information given)
Applicant's summary and conclusion
- Executive summary:
Kinkead (1977):
10 rats were exposed to an atmosphere essentially saturated with 4-nitrotoluene for four hours (rat: 152 ppm = 851 mg/m³) according to a method similar to OECD guideline 403 with deviations (Analytical purity not reported. Animal housing conditions not reported. Only one dose concentration tested). All animals were observed for signs of toxicity and mortality during exposure and for the 14-days immediately following exposure. Animals were weighed immediately prior to exposure and again at 14 days postexposure on survivors.
Determination of the LC50 was made by probit method (Finney, 1952, Probit Analysis, 2nd Edition, King Review Press).
No death occurred during exposure or during the subsequent 14 day post exposure observation period. No lesions attributable to exposure could be discovered during gross pathological evaluation, neither in rats nor in mice.
LC50 was estimated to be 851 mg/m³
On the basis of these results 4 -nitrotoluene can be classified as T; R23, toxic by inhalation and Acute Tox 3 H331 (Toxic if inhaled).
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