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EC number: 200-822-1 | CAS number: 74-93-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- From 1993-10-07 to 1993-11-05
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- GLP compliance:
- yes
- Type of study:
- guinea pig maximisation test
Test material
- Reference substance name:
- Sodium methanethiolate
- EC Number:
- 225-969-9
- EC Name:
- Sodium methanethiolate
- Cas Number:
- 5188-07-8
- IUPAC Name:
- sodium methanethiolate
- Details on test material:
- Test article name : Sodium methylmercaptide
CAS RN: 5188-07-8
Origin: Elf Aquitaine, Lacq
Batch: 93-7074
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- other: Dunkin-Hartley
- Sex:
- male/female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: Centre d'élevage Lebeau, 78950 Gambais, France
- Age at study initiation: no data
- Weight at study initiation: 404 +/- 26 g for males and 410 +/- 20 g for females
- Housing: individually in polycarbonate cages
- Diet (ad libitum): Guinea-pigs sustenance reference 106 diet, UAR, France
- Water (e.g. ad libitum): filtered tap water
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 3
- Humidity (%): 50 +/- 20
- Air changes: non-recycled and filtered
- Photoperiod (hrs dark / hrs light): 12/12
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- intradermal and epicutaneous
- Vehicle:
- physiological saline
- Concentration / amount:
- 1st application: Induction 1 % active substance intracutaneous
2nd application: Induction 1 % active substance occlusive epicutaneous
3rd application: Challenge 10 % active substance occlusive epicutaneous
Challengeopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- physiological saline
- Concentration / amount:
- 1st application: Induction 1 % active substance intracutaneous
2nd application: Induction 1 % active substance occlusive epicutaneous
3rd application: Challenge 10 % active substance occlusive epicutaneous
- No. of animals per dose:
- 10 for control, 20 for the test substance
- Details on study design:
- Thirty guinea-pigs (15 males and 15 females) were allocated to 2 groups: a control group 1 (5 males and 5 females) and a treated group 2 (10 males and 10 females). The sensitization potential of the test substance was evaluated after a 10-day induction period during which time the animals were treated with the vehicle (control group) or the test substance (treated group).
On day 1, in presence of Freund's complete adjuvant, 0.1 ml of the test substance at a concentration of 1 % in the vehicle was administered by intradermal route.
On day 8, 0.5 ml of the test substance at a concentration of 1 % in the vehicle was applied by cutaneous route during 48 hours by means of an occlusive dressing.
After a period of 12 days without treatment, a challenge cutaneous application of 0.5 ml of the vehicle (left flank) and 0.5 ml of the test substance at a concentration of 10% in the vehicle (right flank) were administered to all animals. The test substance and the vehicle were prepared on a dry compress then applied to the skin and held in place for 24 hours by means of an occlusive dressing. Cutaneous reactions on the challenge application sites were then evaluated 24 and 48 hours after removal of the dressing. After the final scoring period, the animals were sacrificed. No skin samples were taken from the challenge application sites from all the animals. - Challenge controls:
- 0.5 ml of the vehicle (left flank)
- Positive control substance(s):
- yes
- Remarks:
- The sensitivity of the guinea-pigs in C.I.T. experimental conditions were checked in a concurrent study with a positive sensitizer: Dinitro 2.4 Chlorobenzene (DNCB).
Study design: in vivo (LLNA)
- Positive control substance(s):
- other: DCNB
Results and discussion
- Positive control results:
- The guinea pig showed a satisfactory sensitization response in 100 % using the positive sensitizer (DCNB).
In vivo (non-LLNA)
Resultsopen allclose all
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 0.5 ml of a 10% solution
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- none
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: test group. Dose level: 0.5 ml of a 10% solution. No with. + reactions: 0.0. Total no. in groups: 10.0. Clinical observations: none.
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 0.5 ml of a 10% solution
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- none
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 48.0. Group: test group. Dose level: 0.5 ml of a 10% solution. No with. + reactions: 0.0. Total no. in groups: 10.0. Clinical observations: none.
- Reading:
- 1st reading
- Group:
- positive control
- Dose level:
- 0.5 ml of a 0.5% solution
- No. with + reactions:
- 5
- Total no. in group:
- 5
- Remarks on result:
- other: Reading: 1st reading. Group: positive control. Dose level: 0.5 ml of a 0.5% solution. No with. + reactions: 5.0. Total no. in groups: 5.0.
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- positive control
- Dose level:
- 0.5 ml of a 0.5% solution
- No. with + reactions:
- 5
- Total no. in group:
- 5
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 48.0. Group: positive control. Dose level: 0.5 ml of a 0.5% solution. No with. + reactions: 5.0. Total no. in groups: 5.0.
Any other information on results incl. tables
No clinical signs and no deaths were noted. After 24 and 48
hours following removal of the dressing of the cutaneous
challenge (test substance), no cutaneous reactions were
recorded.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
- Conclusions:
- According to the maximization method established by
Magnusson and Kligman, no cutaneous reactions attributable
to the sensitization potential of the test substance, SODIUM
METHYLMERCAPTIDE, at the maximum non-irritant concentration
of 10% were observed in guinea-pigs.
Classification: not sensitizing - Executive summary:
Sodium methanethiolate was tested in an OECD Test Guideline 406 skin sensitization study (maximization test) with guinea pigs. Induction was accomplished by an intradermal injection of a 1% solution of sodium methanethiolate in Freund’s adjuvant on day 1 followed by a topical application of a 1% solution of sodium methanethiolate on day 8 (covered for 48 hours) to 10 animals/sex in the treated group and 5 animals/sex in the control. On day 22, a challenge dose of a 10% solution of sodium methanethiolate was applied topically (covered for 24 hours). Skin reactions were evaluated 24 and 48 hours following the removal of the dressing after the challenge dose. No clinical signs or deaths were observed. At 24 and 48 hours following the removal of the dressing after the challenge dose, no cutaneous reactions were recorded. It was concluded that sodium methanethiolate is not a skin sensitizer. Satisfactory sensitization response was observed using the positive control, dinitrochlorobenzene.
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