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EC number: 200-822-1 | CAS number: 74-93-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- from 06/07/99 to 03/05/00
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: 1a: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Sodium methanethiolate
- EC Number:
- 225-969-9
- EC Name:
- Sodium methanethiolate
- Cas Number:
- 5188-07-8
- IUPAC Name:
- sodium methanethiolate
- Details on test material:
- - Name of test material: sodium methyl mercaptide at 32.9 % in water
- Lot/batch No.: SMM33 990103935
- Physical state: clear liquid at 40 °C
- Solubility: totally soluble at 20 °C
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
not relevant
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- no data
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- A stock solution was prepared before the beginning of the test, by vigorously mixing 8 mg of the substance with 1 liter of dilution water for 24 hours.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna Straus
- Strain: Clone A (Clone 5)
- Age at study initiation: < 24h old
- Breeding colony maintained in the laboratory in an Elendt M7 medium , supplemented with algal based feed (Raphidocelis subcapitata).
- Organisms were selected by sieving.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- no data
- Test temperature:
- 19±1°C
- pH:
- from 7.93 to 8.22
- Dissolved oxygen:
- from 9.0 to 9.6 mg/L
- Nominal and measured concentrations:
- Nominal concentrations: 0.6 - 1.0 - 1.7 - 2.9 and 5.0 mg/L
Measured concentrations: 0.83 - 1.32 - 2.46 - 4.38 and 7.47 mg/L
Geometric progression with a factor of 1.7. An untreated control was also included. - Details on test conditions:
- TEST SYSTEM
- Test vessel: 120 mL test glassware was entirely filled with test solutions and stoppered with PTFE bungs and sealed with aluminium caps
- Type: closed
- No. of organisms per concentration: 20 daphnids per concentration
- 4 replicates , 5 individuals per replicate
OTHER TEST CONDITIONS
- Darkness
WATER PARAMETERS
- Ca+Mg ions = 2.5 mmol/l
- Ca/Mg = 4
- Na/K = 10 - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 1.32 - 2.46 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 4.38 - 7.37 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- The appearance of the test solution was visually checked at the beginning and at the end of the test. Solutions were found to be clear and colourless over the period of the test. No precipitation was observed at the end of the test.
- Results with reference substance (positive control):
- Potassium dichromate: EC50-24h = 1.6 mg/L
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- see conclusions
- Conclusions:
- The study was performed in compliance with its quality criteria:
- Test daphnids in the control were not trapped at the surface of the water.
- Concentration of dissolved oxygen in the test vessel remained above 2 mg/L at the end of the test and pH did not vary by more than 1 unit.
- No more than 10 % of the daphnids immobilized in the control at the end of the test.
- Concentrations of the test substance were maintained within 80 % of the initial concentrations throughout the duration of the test. - Executive summary:
Acute toxicity to Daphnia magna has been investigated according to OECD Guideline 202 and EU Method C.2.
Daphnia magna were exposed for 48 hours to an aqueous solution of sodium methanethiolate at different nominal concentrations of 0.6 - 1.0 - 1.7 - 2.9 and 5.0 mg/L.
EC 50 - 48h determined was in the range of 1.32 - 2.46 mg/L and EC50 - 24h was in the range of 4.38 - 7.37 mg/L.
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