Registration Dossier
Registration Dossier
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EC number: 212-079-0 | CAS number: 760-23-6
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: MIGRATED DATASET. Original reference not translated.
Data source
Reference
- Title:
- No information
- Author:
- Gizhlaryan, M.S. et al.: Gig. Sanit. 7, 77-78 (1986)
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No data
- GLP compliance:
- no
- Remarks:
- GLP was not mandatory at the tiem of the study
Test material
- Reference substance name:
- 3,4-dichlorobut-1-ene
- EC Number:
- 212-079-0
- EC Name:
- 3,4-dichlorobut-1-ene
- Cas Number:
- 760-23-6
- Molecular formula:
- C4H6Cl2
- IUPAC Name:
- 3,4-dichlorobut-1-ene
- Details on test material:
- - Name of test material (as cited in study report): 3,4-dichlorobut-1-ene
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Duration of treatment / exposure:
- over the whole gestation period
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.01, 0.1 or 1.0 mg/kg bw
Basis:
- Control animals:
- yes
- Details on study design:
- Sex: female
Results and discussion
Results: maternal animals
Maternal developmental toxicity
- Details on maternal toxic effects:
- Maternal toxic effects:yes
Details on maternal toxic effects:
The dose of 1.0 mg/kg bw led to a significant enhancement of post-implantation losses. 0.1 mg/kg bw caused an increase of pre-implantation losses. Histological examinations revealed changes of placenta.
Results (fetuses)
- Details on embryotoxic / teratogenic effects:
- Embryotoxic / teratogenic effects:yes
Details on embryotoxic / teratogenic effects:
Histological examinations revealed haemorrhages in embryos (brain and peritoneum) as well as oedema and changes in liver, brain and kidneys. The dose of 0.01 mg/kg bw was tolerated without any damages.
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Applicant's summary and conclusion
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