Registration Dossier
Registration Dossier
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EC number: 939-066-9 | CAS number: -
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Docosanoic acid
- EC Number:
- 204-010-8
- EC Name:
- Docosanoic acid
- Cas Number:
- 112-85-6
- IUPAC Name:
- docosanoic acid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- 0 (control), 2000 mg/L
- No. of animals per sex per dose:
- 5 animals per sex and per dose.
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, gross pathology
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths occurred of either males or females in the treated groups.
- Clinical signs:
- No effects were found on general condition.
- Body weight:
- No effects were found on body weight changes.
- Gross pathology:
- No effects were found on autopsy findings.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified (CLP Regulation EC no. 1272/2008)
- Conclusions:
- The LD50 of docosanoic acid in rats after a single oral dose was >2000 mg/kg bw.
- Executive summary:
An acute oral toxicity test was performed on docosanoic acid according to OECD Guideline 401. 5 rats per sex and per dose were exposed to 0 (control) and 2000 mg/kg bw test item by a single gavage route. No deaths occurred of either males or females in the treated groups. No effects were found on general condition, body weight changes or autopsy findings. The LD50 was determined to be >2000 mg/kg bw both for males and females.
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