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EC number: 221-416-0 | CAS number: 3088-31-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- chronic toxicity: dermal
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- DERMAL TOXICITY OF SODIUM LAURYL SULFATE
- Author:
- STEVEN CARSO, BERNARD L. OSER
- Year:
- 1 964
- Bibliographic source:
- J. soc. cos. CHEM. 15, 137-147 (1964)
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Toxicity of Sodium Lauryl Sulphate was assessed in Rabbits in a 90-day study
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Sodium dodecyl sulphate
- EC Number:
- 205-788-1
- EC Name:
- Sodium dodecyl sulphate
- Cas Number:
- 151-21-3
- Molecular formula:
- C12H25NaO4S
- IUPAC Name:
- sodium dodecyl sulfate
- Details on test material:
- - Name of test material : Sodium Lauryl Sulphate (sodium dodecyl sulphate)
- Molecular formula : NaC12H25SO4
- Molecular weight : 288.372
- Substance type: Organic
- Physical state: Solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Diet : ad libitum
- Water : ad libitum
- Acclimation period : 6 hrs
Administration / exposure
- Type of coverage:
- other: Intact and abraded skin
- Vehicle:
- water
- Details on exposure:
- PREPARATION OF DOSING SOLUTIONS:
20% solution of SLS in water was applied daily to the intact and abraded skin of rabbits - Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 90 days
- Frequency of treatment:
- Dosage was applied daily, five days a week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 6, 60 or 150 mg/kg/day
Basis:
nominal per unit area
- No. of animals per sex per dose:
- Control:
2 males, 1 female
6 mg/kg/day:
3 males, 3 females
60 mg/kg/day:
3 males, 3 females
150 mg/kg/day:
4 males, 2 females - Control animals:
- yes, concurrent vehicle
- Details on study design:
- The dosage levels selected represented 0, 1, 10 and 25% of the acute dermal LD50 (rounded off at 600 mg. per kg.)
Examinations
- Observations and examinations performed and frequency:
- CAGE SIDE OBSERVATIONS: No Data
DETAILED CLINICAL OBSERVATIONS: No Data
BODY WEIGHT: No Data
FOOD CONSUMPTION AND COMPOUND INTAKE (if feeding study):
- Food consumption for each animal determined and mean daily diet consumption calculated as g food/kg body weight/day: No Data
- Compound intake calculated as time-weighted averages from the consumption and body weight gain data: No Data
FOOD EFFICIENCY:
- Body weight gain in kg/food consumption in kg per unit time X 100 calculated as time-weighted averages from the consumption and body weight gain data: No Data
WATER CONSUMPTION AND COMPOUND INTAKE (if drinking water study): No Data
OPHTHALMOSCOPIC EXAMINATION: No Data
HAEMATOLOGY: Yes
- total erythrocyte counts, Hematocrit, hemoglobin, total and differential leukocyte counts were conducted initially prior to start of dosage and at 21 and 90 days
CLINICAL CHEMISTRY: Yes
- blood glucose and urea nitrogen concentration were conducted initially prior to start of dosage and at 21 and 90 days
URINALYSIS: Yes
- urine analyses were conducted initially prior to start of dosage and at 21 and 90 days.
NEUROBEHAVIOURAL EXAMINATION: No Data - Sacrifice and pathology:
- GROSS PATHOLOGY: Yes
All the abraded rabbits and one male and one female each of the intact skin group were sacrificed at 21 days and the remainder of the intact animals at 90 days. Those that died and the survivors were autopsied and all major tissues fixed in 10% formalin.
HISTOPATHOLOGY: Yes
Nine tissues including thyroid, pancreas, heart, liver, kidneys, adrenals, skin, brain and bone marrow were processed, stained with hematoxylin and eosin and examined microscopically
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Mortality:
- mortality observed, treatment-related
- Body weight and weight changes:
- effects observed, treatment-related
- Food consumption and compound intake (if feeding study):
- not examined
- Food efficiency:
- not examined
- Water consumption and compound intake (if drinking water study):
- not examined
- Ophthalmological findings:
- not examined
- Haematological findings:
- no effects observed
- Clinical biochemistry findings:
- no effects observed
- Urinalysis findings:
- no effects observed
- Behaviour (functional findings):
- not examined
- Organ weight findings including organ / body weight ratios:
- not examined
- Gross pathological findings:
- no effects observed
- Histopathological findings: non-neoplastic:
- no effects observed
- Details on results:
- Clinical signs and mortality :
Two rabbits at the 150 mg. per kg. level died, one on the 21st day and one on the 56th day of the test
Body weight and weight gain :
There is no significant differences in growth responses between the untreated controls and those sacrificed at 21 days. These latter rabbits generally tended to show maintenance or a slight loss of body weight. Those that continued on test for 90 days generally showed a slight weight gain.
Haematology :
No significant alterations in total erythrocytes, hemoglobin or Hematocrit values
Clinical chemistry :
Blood glucose and urea nitrogen values reveal no aberrant findings at either 21 or 90 days.
Gross pathology :
Gross examination at necropsy failed to indicate any significant dose-related alterations in tissue pathology. Only the two rabbits that died in the group receiving SLS at 150 mg. per kg. showed evidence of significant deleterious gross change. Necropsy observations in rabbit that died at 21 days revealed marked diarrhea and mucosal sloughing of the gastrointestinal tract. Death appeared to be unrelated to the test treatment. The animal that died after 56 days of test showed evidence of pulmonary congestion, the lungs appearing consolidated and hemorrhagic with moderate quantities of fluid in the pleural cavity.
Histopathology :
No significant systemic tissue changes observed
Effect levels
open allclose all
- Dose descriptor:
- LOAEL
- Effect level:
- 150 other: mg/kg/day
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: Mortality, body weight, Hematology, Clinical chemistry, Gross pathology, histopathology
- Dose descriptor:
- NOAEL
- Effect level:
- 60 other: mg/kg/day
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: Mortality, body weight, Hematology, Clinical chemistry, Gross pathology, histopathology
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The Low Observed Adverse Effect Level (LOAEL) of Sodium Lauryl Sulphate in a 90-day study on rabbits was observed at a dose concentration of 150 mg/kg/day.
The No Observed Adverse Effect Level (NOAEL) of Sodium Lauryl Sulphate in the same study was observed at a dose concentration of 60 mg/kg/day. - Executive summary:
The purpose of this study was to evaluate the toxicity of Sodium Lauryl Sulphate by dermal application.20% solution of Sodium Lauryl Sulphatein water was applieddaily, for five days a week,for 90 daysto the intact and abraded skin of rabbits at a dose concentration of0, 6, 60 or 150 mg/kg/day.Animals were kept in stocks for six hours and allowed food and water ad libitum each day. They were removed from the stocks and returned to their cages at the end of six hours.
Mortality, body weight, hematology, clinical chemistry, gross pathology, and histopathology were analyzed.
Two rabbits died on day 21 and 56 at the highest dose. Slight weight gain was observed for those that continued on test for 90 days. No significant alterations in total erythrocytes, hemoglobin, hematocrit, blood glucose and urea nitrogen values. Gross examination at necropsy failed to indicate any significant dose-related alterations in tissue pathology. Hence the NOAEL and LOAEL was considered to be 60 and 150 mg/kg/day respectively.
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