Registration Dossier
Registration Dossier
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EC number: 604-200-4 | CAS number: 14078-41-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidlines and/or minor methodological deficiencies, which do not affect the quality of the relevant results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 bis (Acute Oral Toxicity - Fixed Dose Procedure)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- 6,6'-di-tert-butyl-4,4'-dimethoxy-[1,1'-biphenyl]-2,2'-diol
- EC Number:
- 604-200-4
- Cas Number:
- 14078-41-2
- Molecular formula:
- C22 H30 O4
- IUPAC Name:
- 6,6'-di-tert-butyl-4,4'-dimethoxy-[1,1'-biphenyl]-2,2'-diol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- arachis oil
- Doses:
- 300 mg/kg
2000 mg/kg - No. of animals per sex per dose:
- 300 mg/kg - 1
2000 mg/kg - 5 - Control animals:
- no
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality observed
- Clinical signs:
- other: No signs of systemic toxicity were noted during the observation period
- Gross pathology:
- No abnormalities were noted at necropsy
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- The acute oral median lethal dose (LD50) of the test material in the female wistar strain rat was estimated to be greater than 2000 mg/kg bodyweight. Therefore the material is unclassified according to the Globally Harmonised System.
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