[1,1'-Biphenyl]-2,2'-diol, 3,3'-bis(1,1-dimethylethyl)-5,5'-dimethoxy-

Water solubility

Administrative data

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP- and Guideline-Study with no or minor deviations from standard test guidlines and/or minor methodological deficiencies, which do not affect the quality of the relevant results.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2008

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Test material

Test material information

Constituent 1

Reference substance name:

6,6'-di-tert-butyl-4,4'-dimethoxy-[1,1'-biphenyl]-2,2'-diol

EC Number:

604-200-4

Cas Number:

14078-41-2

Molecular formula:

C22 H30 O4

IUPAC Name:

6,6'-di-tert-butyl-4,4'-dimethoxy-[1,1'-biphenyl]-2,2'-diol

Results and discussion

Water solubility

Water solubility:

< 0.06 mg/L

Temp.:

20 °C

pH:

ca. 7 - 8

Any other information on results incl. tables

After a preliminary test the water solubility of the test item was determined with the column elution method. Two determinations were performed but no evaluable substance peak was detected. Due to this the flask method with preincubation at 30°C was choosen to determine the endpoint, because the equilibration and dissolving time is extended with this method. The test was performed with three flasks and the equilibration time at 20°C was 72 h before the suspension was analyzed by HPLC. The water solubility which was found with the three samples had a good repeatebility, but the avarage concentration of 0.05 mg/l was slightly below the limit of quantification (=0.06 mg/l) of the HPLC-Method. As a result of this limitation the water solubility is reported to be below the limit of quantification of the method.

Applicant's summary and conclusion

Conclusions:

Interpretation of results (migrated information): insoluble (< 0.1 mg/L)
The test substance was found to be practically insoluble. The solubility was slightly below the limit of quantification (=0.06 mg/l) of the HPLC-Method.