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EC number: 254-879-2 | CAS number: 40306-75-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Link to relevant study records
- Endpoint:
- two-generation reproductive toxicity
- Remarks:
- based on test type (migrated information)
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- other: Estimated data
- Principles of method if other than guideline:
- Prediction is done using QSAR Toolbox version 2.3.
- GLP compliance:
- no
- Species:
- rat
- Strain:
- other: Rattus norvegicus
- Sex:
- male/female
- Route of administration:
- oral: unspecified
- Type of inhalation exposure (if applicable):
- not specified
- Vehicle:
- unchanged (no vehicle)
- Duration of treatment / exposure:
- 10 weeks
- Dose descriptor:
- other: not specified
- Based on:
- not specified
- Sex:
- not specified
- Basis for effect level:
- other: not specified
- Remarks on result:
- other: not specified
- Critical effects observed:
- not specified
- System:
- other: not specified
- Organ:
- not specified
- Dose descriptor:
- LOEL
- Generation:
- F2
- Effect level:
- 108.763 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: not specified
- Remarks on result:
- other: not specified
- Critical effects observed:
- not specified
- System:
- other: not specified
- Organ:
- not specified
- Reproductive effects observed:
- not specified
- Treatment related:
- not specified
- Conclusions:
- 3-acetamido-5-amino-4-hydroxybenzenesulphonic acid shall not exhibit toxic effect to Rattus norvegicus below the mentioned dose.
- Executive summary:
The two generation reproductive toxicity LOEL (Lowest observed effect level) of 3-acetamido-5-amino-4-hydroxybenzenesulphonic acid in Rattus norvegicus was observed at a dose concentration of 108.7634 mg/kg bw/day.This indicates that 3-acetamido-5-amino-4-hydroxybenzenesulphonic acid shall not exhibit toxic effect to Rattus norvegicus below the above mention dose. This conclusion has been drawn based on the QSAR prediction done on the target chemical.
Reference
The
prediction was based on dataset comprised from the following
descriptors: LOEL
Estimation method: Taking average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
(((("a"
and ("b"
and (
not "c")
)
)
and "d" )
and ("e"
and (
not "f")
)
)
and ("g"
and "h" )
)
Domain
logical expression index: "a"
Similarity
boundary:Target:
c1(N)c(O)c(NC(C)=O)cc(S(=O)(=O)O)c1
Threshold=50%,
Dice(Atom pairs)
Domain
logical expression index: "b"
Referential
boundary: The
target chemical should be classified as No alert found by DNA binding by
OECD
Domain
logical expression index: "c"
Referential
boundary: The
target chemical should be classified as Aliphatic tertiary amines OR
Aromatic nitro OR MA: Iminium Ion Formation OR MA: Nitrenium Ion
Formation OR MA: P450 Mediated Activation to Quinones and Quinone-type
Chemicals OR Mechanistic Domain: Michael addition OR Mechanistic Domain:
SN1 OR Methylenedioxyphenyl OR Primary aromatic amine by DNA binding by
OECD
Domain
logical expression index: "d"
Referential
boundary: The
target chemical should be classified as High (Class III) by Toxic hazard
classification by Cramer (with extension)
Domain
logical expression index: "e"
Referential
boundary: The
target chemical should be classified as No alert found by Protein
binding by OASIS
Domain
logical expression index: "f"
Referential
boundary: The
target chemical should be classified as alpha,beta-carbonyl compounds
with polarized double bonds OR Carbamates OR MA: Direct acylation
involving a leaving group OR MA: Michael addition on conjugated systems
with electron withdrawing group OR MA: Nucleophilic substitution at sp3
Carbon atom OR MA: Pyrazolones and pyrazolidinones derivatives OR
Mechanistic Domain: Acylation OR Mechanistic Domain: Michael addition OR
Mechanistic Domain: Schiff base formation OR Mechanistic Domain: SN2 OR
N-acylamides OR N-acylsulphonamides OR Pyrazolones and pyrazolidinones
OR Thiophosphates by Protein binding by OASIS
Domain
logical expression index: "g"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= -4.82
Domain
logical expression index: "h"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= 1.49
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
- 108.763 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
- Quality of whole database:
- K2 level data has been obtained from QSAR model considered by OECD.
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
Toxicity to reproduction
The two generation reproductive toxicity LOEL (Lowest observed effect level) of 3-acetamido-5-amino-4-hydroxybenzenesulphonic acid in Rattus norvegicus was observed at a dose concentration of 108.7634 mg/kg bw/day.This indicates that 3-acetamido-5-amino-4-hydroxybenzenesulphonic acid shall not exhibit toxic effect to Rattus norvegicus below the above mention dose. This conclusion has been drawn based on the QSAR prediction done on the target chemical.
Short description of key information:
Study indicates that 3-acetamido-5-amino-4-hydroxybenzenesulphonic acid shall not exhibit toxic effect to Rattus norvegicus.
Justification for selection of Effect on fertility via oral route:
The two generation reproductive toxicity LOEL (Lowest observed effect level) of 3-acetamido-5-amino-4-hydroxybenzenesulphonic acid in Rattus norvegicus was observed at a dose concentration of 108.7634 mg/kg bw/day.This indicates that 3-acetamido-5-amino-4-hydroxybenzenesulphonic acid shall not exhibit toxic effect to Rattus norvegicus below the above mention dose.
Effects on developmental toxicity
Description of key information
LOEL (Lowest observed effect level) of 3-acetamido-5-amino-4-hydroxybenzenesulphonic acid in Oryctolagus cuniculus;Rattus norvegicus was estimated to be 316.1133 mg/kg bw/day.
Link to relevant study records
- Endpoint:
- developmental toxicity
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- other: Estimated data
- Principles of method if other than guideline:
- Prediction is done using QSAR Toolbox version 2.3.
- GLP compliance:
- no
- Species:
- other: Rabbit & Rat
- Strain:
- other: Oryctolagus cuniculus; Rattus norvegicus
- Route of administration:
- oral: unspecified
- Vehicle:
- unchanged (no vehicle)
- Dose descriptor:
- other: not specified
- Based on:
- not specified
- Basis for effect level:
- other: not specified
- Remarks on result:
- other: not specified
- Abnormalities:
- not specified
- Localisation:
- not specified
- Description (incidence and severity):
- not specified
- Dose descriptor:
- LOEL
- Effect level:
- 316.113 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- other: fetotoxicity
- Remarks on result:
- other: not specified
- Abnormalities:
- not specified
- Localisation:
- other: not specified
- Description (incidence and severity):
- not specified
- Developmental effects observed:
- not specified
- Treatment related:
- not specified
- Conclusions:
- 3-acetamido-5-amino-4-hydroxybenzenesulphonic acid] shall not exhibit toxic effect to Oryctolagus cuniculus or Rattus norvegicus by the oral route.
- Executive summary:
The fetotoxicity LOEL (Lowest observed effect level) of 3-acetamido-5-amino-4-hydroxybenzenesulphonic acid on Oryctolagus cuniculus and Rattus norvegicus by oral exposure was observed at a dose concentration of 316.1133 mg/kg bw/day . This indicates that 3-acetamido-5-amino-4-hydroxybenzenesulphonic acid] shall not exhibit toxic effect to Oryctolagus cuniculus or Rattus norvegicus by the oral route below the above mention dose.
Reference
The
prediction was based on dataset comprised from the following
descriptors: LOEL
Estimation method: Taking average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
((((("a"
and ("b"
and (
not "c")
)
)
and ("d"
and (
not "e")
)
)
and "f" )
and "g" )
and ("h"
and "i" )
)
Domain
logical expression index: "a"
Similarity
boundary:Target:
c1(N)c(O)c(NC(C)=O)cc(S(=O)(=O)O)c1
Threshold=50%,
Dice(Atom pairs)
Domain
logical expression index: "b"
Referential
boundary: The
target chemical should be classified as No alert found by DNA binding by
OECD
Domain
logical expression index: "c"
Referential
boundary: The
target chemical should be classified as Aliphatic tertiary amines OR
Aromatic nitro OR Aromatic phenylureas OR MA: Iminium Ion Formation OR
MA: Nitrenium Ion Formation OR MA: P450 Mediated Activation to Quinones
and Quinone-type Chemicals OR MA: SN2 at an sp3 Carbon atom OR
Mechanistic Domain: Michael addition OR Mechanistic Domain: SN1 OR
Mechanistic Domain: SN2 OR Methylenedioxyphenyl OR Primary aromatic
amine OR Sulfonates OR Unsaturated heterocyclic phenylureas by DNA
binding by OECD
Domain
logical expression index: "d"
Referential
boundary: The
target chemical should be classified as No alert found by Protein
binding by OASIS
Domain
logical expression index: "e"
Referential
boundary: The
target chemical should be classified as alpha,beta-carbonyl compounds
with polarized double bonds OR Carbamates OR MA: Direct acylation
involving a leaving group OR MA: Michael addition on conjugated systems
with electron withdrawing group OR MA: Nucleophilic substitution at sp3
Carbon atom OR MA: Pyrazolones and pyrazolidinones derivatives OR
Mechanistic Domain: Acylation OR Mechanistic Domain: Michael addition OR
Mechanistic Domain: Schiff base formation OR Mechanistic Domain: SN2 OR
N-acylamides OR Phosphates OR Pyrazolones and pyrazolidinones OR
Thiophosphates OR Vinyl sulfonyl compounds by Protein binding by OASIS
Domain
logical expression index: "f"
Referential
boundary: The
target chemical should be classified as High (Class III) by Toxic hazard
classification by Cramer (original)
Domain
logical expression index: "g"
Referential
boundary: The
target chemical should be classified as High (Class III) by Toxic hazard
classification by Cramer (with extension)
Domain
logical expression index: "h"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= -4.82
Domain
logical expression index: "i"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= 1.17
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no adverse effect observed
- 316.113 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
- Quality of whole database:
- K2 level data has been obtained from QSAR model considered by OECD.
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Additional information
The fetotoxicity LOEL (Lowest observed effect level) of 3-acetamido-5-amino-4-hydroxybenzenesulphonic acid on Oryctolagus cuniculus and Rattus norvegicus by oral exposure was observed at a dose concentration of 316.1133 mg/kg bw/day . This indicates that 3-acetamido-5-amino-4-hydroxybenzenesulphonic acid] shall not exhibit toxic effect to Oryctolagus cuniculus or Rattus norvegicus by the oral route below the above mention dose.
Justification for selection of Effect on developmental toxicity: via oral route:
The fetotoxicity LOEL (Lowest observed effect level) of 3-acetamido-5-amino-4-hydroxybenzenesulphonic acid in Oryctolagus cuniculus;Rattus norvegicus by oral exposure was observed at a dose concentration of 316.1133 mg/kg bw/day . This indicates that 3-acetamido-5-amino-4-hydroxybenzenesulphonic acid shall not exhibit toxic effect to Oryctolagus cuniculus;Rattus norvegicus by the oral route below the above mention dose.
Justification for classification or non-classification
No reproductive toxicity was observed for 3-acetamido-5-amino-4-hydroxybenzenesulphonic acid on any of the animal used for estimation and this results indicates that 3-acetamido-5-amino-4-hydroxybenzenesulphonic acid shall not exhibit toxic effect and so will not be considered for classification i any of the reproductive category.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.