Registration Dossier
Registration Dossier
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EC number: 219-775-3 | CAS number: 2528-61-2
Endpoint summary
Administrative data
Description of key information
LD50 (rat, oral): >2000 mg/kg
LC50 (4h,rat, inhal.): 0.39 mg/L
dermal: no data
Key value for chemical safety assessment
Additional information
BASF (1998) reported about the acute oral toxicity in rats. Male and female Wistar rats were administered (gavage) concentrations of 200 and 2000 mg/kg (vehicle: olive oil). No mortalities were noted. Clinical signs found were impaired and poor general state, dyspnoea, apathy, abdominal position (only females), staggering, ataxia, atonia (only females) paresis (only females), temor (only males), cyanosis (only males), piloerection, salivation (only males), compulsary gnawing (only males), alopecia (only females), discoloured red urine (only females). No pathological findings were noted. The LD50 was > 2000 mg/kg (both sexes).
BASF (2001) reported an acute inhalation toxicity study. Male and female Wistar rats were offered vapour concentrations of 0.11, 0.34 and 0.51 mg/l for 4 hours. Mortality rates: 0.11 mg/l - no mortalities; 0.34 mg/l - 4 male rats, no female rat; 0.51 mg/l - 5 male and 2 female animals.Clinical signs recorded were irregular, accelerated and intermittent respiration, respiratory sounds (only males), nose/discharge/bloody (only females), apathy, squatting posture, lateral position (only males), piloerection, smeared fur. Gross-pathological findings - animals that died: diffuse dark-red discolouration of all lobes (0.34 and 0.51 mg/l), severe retracted surface (0.51 mg/l); surviving animals: no abnormalities detected. The LC50 value was 0.39 mg/l/4 h for male and female animals.
Data concerning acute dermal toxicity area not available.
Justification for classification or non-classification
Based on the results, the test item is classified as akute toxic for inhalation cat. 1 (H330) according to Regulation (EC) No 1272/2008 (CLP).
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