Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
Toxicity studies are not available for Slag, Pig Iron ladle refining, non-granulated, water-cooled. Read-across to the assessment entity (analogue approach) to slags, steelmaking is applied for the assessment of Slag, Pig Iron ladle refining, non-granulated. Based on results of a leaching experiment performed with the target substance (i.e., Slag, Pig Iron ladle refining, non-granulated, water-cooled) and the source substance (i.e., slags steelmaking) solved metal ion concentrations of the target substance are similar to the solved metal concentrations of the source substance. Read-across is fully justified and discussed in detail in the RAAF document attached on IUCLID section 13.
No indication for reproductive/developmental toxicity, based on negative test results from available in vitro and in vivo mutagenicity studies.
No harmonised classification for reproductive/developmental toxicity for the components of the slags.
Effect on fertility: via oral route
- Endpoint conclusion:
- no study available
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
Short description of key information:
No evidence from acute tests or
other data for any reproductive effect. No data available from studies
dedicated especially to reproduction toxicity. As slags are similar to
natural rock, no reporductive effects have to be expected.
Effects on developmental toxicity
Description of key information
Toxicity studies are not available for Slag, Pig Iron ladle refining, non-granulated, water-cooled. Read-across to the assessment entity (analogue approach) to slags, steelmaking is applied for the assessment of Slag, Pig Iron ladle refining, non-granulated. Based on results of a leaching experiment performed with the target substance (i.e., Slag-s, Pig Iron ladle refining, non-granulated, water-cooled) and the source substance (i.e., slags steelmaking) solved metal ion concentrations of the target substance are similar to the solved metal concentrations of the source substance. Read-across is fully justified and discussed in detail in the RAAF document attached on IUCLID section 13.
No evidence from acute tests or other data for developmental toxicity or teratogenicity.
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Toxicity to reproduction: other studies
Description of key information
No indication for reproductive/developmental toxicity, based on negative test results from available in vitro and in vivo mutagenicity studies.
Justification for classification or non-classification
No indication for reproductive/developmental toxicity, based on negative test results from available in vitro and in vivo mutagenicity studies.
No harmonised classification for reproductive/developmental toxicity for the components of the slags.
The physico-chemical properties of ferrous slags are low solubility in water, low extractability of components from ferrous slags, and lack of toxicological bioavailable fraction/systemic bioavailability of metals. Furthermore, ferrous slags have no PBT (persistent, bioaccumulative and toxic) or vPvB (very persistent and very bioaccumulative) properties.
I the likely route of human exposure is inhalation and there is no toxicity effects of particular concern observed in animal inhalation studies, and results obtained from suitable in vitro studies demonstrate no certain dangerous property of ferrous slags.
Finally, previous risk assessments of slags provide sufficient supporting evidence that reproduction and developmental toxicity can reliably be excluded.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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