Ladle skimming slag, Ladle furnace refining, slag, Ferrous slag

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2006 - 2007

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Guideline study with acceptable restrictions

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Unnamed

Year:

2006

Reference 2

Reference Type:

publication

Title:

Unnamed

Year:

2007

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Test material

Test material information

Constituent 1

Reference substance name:

Slag, pig iron ladle refining, non-granulated, water-cooled

Molecular formula:

not applicable because slags are UVCB

IUPAC Name:

Slag, pig iron ladle refining, non-granulated, water-cooled

Details on test material:

In order to substantiate this evaluation, the Tecarn-Tecnologia Ambiental Ltda accredited before the Ministry of Agriculture and is holder of bio-safety certificates.
SMS samples were collected in CST´s processing plants. The crushed stone is from Brasitalia quarry, located in the municipality of Serra, Brasilia. Crushed stone samples were collected and prepared by the company Kaerne Engenharia Ltda. In compliance with the method defined in NBR 10.007.2007.

Test animals

Species:

rabbit

Strain:

New Zealand White

Details on test animals or test system and environmental conditions:

adult, healthy (2 to 3 kg)

Test system

Type of coverage:

open

Preparation of test site:

shaved

Vehicle:

water

Controls:

no

Duration of treatment / exposure:

4 h

Observation period:

24 h and 72 h for erythema and edema

Number of animals:

3

Details on study design:

Surrounding untreated skin areas served as controls for the test.

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

72 h

Score:

ca. 0

Reversibility:

fully reversible

Remarks on result:

other: SMS (data estimated by IUCLID editor)

Results 2

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

72 h

Score:

ca. 0

Reversibility:

fully reversible

Remarks on result:

other: crusehd stone from quarry in the vicinity of Serra, Brasilia (data estimated by IUCLID editor)

Results 3

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

24/48 h

Remarks on result:

not measured/tested

Irritant / corrosive response data:

neither irritating nor corrosive

Applicant's summary and conclusion

Interpretation of results:

not irritating

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

Slags, steelmaking (SMS) and natural stone form a quarry in Serra, Brasilia, are neither corrosive nor irritant to the skin

Executive summary:

To determine the irritant and corrosive potential to skin of slags, steelmaking (SMS), and crushed stone from a quarry in the vicinity of Serra, Brasilia, tests were performed following OECD guideline 404. Fine-ground SMS and crushed stone were dosed, in their original form, at 0.5 g/animal under semi-occlusive dressing for 4 h to an undamaged, dorsal skin area of each 6 cm²of 3 albino rabbits. After dosing, the patches were removed and skin reaction to the test material was assessed after 1 h, 24 h, 48 h, and 72 h. As no irritation was observed during 72 h, observation was terminated.

SMS and the tested natural stone are neither corrosive nor irritant to the skin, and do not need to be classified as corrosive or irritant. No signal word and no hazard statement is required.