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Diss Factsheets
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EC number: 932-389-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- April 1981-June 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- This study was conducted according to the principles and practices of Good Laboratory Practice. A Quality Assurance statement is included in the report. This was an investigative study therefore not required to comply with any current regulatory guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- This 28-day oral toxicity study in the rat on cyhalothrin was conducted to investigate the reversibility of treatment related effects. This was an investigative study therefore not required to comply with any current regulatory guideline.
- GLP compliance:
- yes
Test material
- Reference substance name:
- Reaction mass of (R)-cyano(3-phenoxyphenyl)methyl rel-(1R,3R)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate and (R)-cyano(3-phenoxyphenyl)methyl rel-(1S,3S)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate
- EC Number:
- 932-389-6
- Molecular formula:
- C23H19ClF3NO3
- IUPAC Name:
- Reaction mass of (R)-cyano(3-phenoxyphenyl)methyl rel-(1R,3R)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate and (R)-cyano(3-phenoxyphenyl)methyl rel-(1S,3S)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate
Constituent 1
Test animals
- Species:
- rat
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The study is considered to be reliable with restrictions. The results are sufficiently detailed and unambiguous as to be adequate for risk assessment, classification and labeling.
- Executive summary:
In a subchronic toxicity study, 250 ppm cyhalothrin in diet was administered to a group of 32 male rats for 28 days. A similar group of rats received control diet. After this period eight rats per group were killed and examined. The remaining rats were fed control diet for periods of 7, 14 or 28 days after cessation of treatment, and a further eight rats per group were killed and examined at each of these time intervals.
Preliminary feeding studies(Faupel et al 1980, Moyes et al 1981) in rats have shown that cyhalothrin produced treatment related effects on bodyweight, small increases in liver weight, proliferation of smooth endoplasmic reticulum (SER) and elevated hepatic aminopyrine-N-demethylase (APDM) activity at a dietary level of 250 ppm cyhalothrin. Similar effects were seen on feeding this level of cyhalothrin to rats for 90 days, but the liver weights were unaffected(Lindsay et al 1981). Although cyhalothrin induced changes were seen in both sexes, male rats were more susceptible. The aim of this study was to determine whether treatment related liver changes were reversible, as an aid to establishing their significance.
A decrease in bodyweight gain was seen in the 250 ppm cyhalothrin group, which persisted during the 28 day recovery period.
Proliferation of the hepatic smooth endoplasmic reticulum and elevated hepatic aminopyrine-N-demethylase activity were also seen in the treatment group. These effects had reversed 7 days after the cessation of treatment with cyhalothrin and were considered to be physiological adaptive changes rather than a toxicological effect.
Administration of 250 ppm cyhalothrin in diet produced reversible and adaptive changes in the liver, characterised by SER proliferation and increased APDM activity. This level of cyhalothrin also produced adecrease in bodyweight gain which was still apparent 28 days after the cessation of treatment.
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