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EC number: 932-389-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study similar to guideline with minor restrictions and under GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- Five male and five female rats per dose group were used.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Reaction mass of (R)-cyano(3-phenoxyphenyl)methyl rel-(1R,3R)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate and (R)-cyano(3-phenoxyphenyl)methyl rel-(1S,3S)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate
- EC Number:
- 932-389-6
- Molecular formula:
- C23H19ClF3NO3
- IUPAC Name:
- Reaction mass of (R)-cyano(3-phenoxyphenyl)methyl rel-(1R,3R)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate and (R)-cyano(3-phenoxyphenyl)methyl rel-(1S,3S)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Alderley Park SPF-derived albino
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Animal Breeding Unit, ICI PLC, Alderley Park, Macclesfield, Cheshire, UK
- Age at study initiation: 5-7 weeks
- Weight at study initiation: males: 133-175 g, females: 112-152 g
- Fasting period before study: 17-20 h
- Housing: at a maximum of 5 in stainless steel cages
- Diet (e.g. ad libitum): Porton Combined Diet, ad libitum
- Water (e.g. ad libitum): tap water ad libitum
- Acclimation period: minimum 6 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): approximately 21°C
- Humidity (%): 55%
- Air changes (per hr): 20-30
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- DOSE VOLUME APPLIED: 10 mL/kg bw
DOSAGE PREPARATION: The dose level was altered by varying the concentration of the dosed preparation. - Doses:
- nominal: 25, 100, 200, 300, and 400 mg/kg bw
analytical: 25.3, 98, 196, 294, and 335 mg/kg bw - No. of animals per sex per dose:
- 5 males and 5 females were used per dose group
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 15 days
- Frequency of observations: at about 1 and 5 h after dosing and then daily until day 15
- Frequency of weighing: at day 0 (before dosing), the day of dosing (day 1), and on day 3, 4, 8, and 15 - Statistics:
- The acute oral LD50 values and the 95% confidence limits were calculated by the probit method.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 166 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 52 - 318
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 114 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 33 - 191
- Mortality:
- No animal died in the 25.3 mg/kg bw dose group but all animals died or were killed in extremis in the 335 mg/kg bw dose group. At the remaining dose levels the proportion of the animals not surviving varied . All deaths occurred between days 1 and 4. Mortality data are given in table 1.
- Clinical signs:
- other: Clinical signs of toxicity were observed in most of the animals at all dose levels within 6 h of dosing and persisted up to day 8 (most animals), 11 (one animal) or 13 (two animals). Most common effects were decreased activity, dehydration, piloerection,
Any other information on results incl. tables
Table 1: Cumulative mortality data for rats after single administration of cyhalothrin; five males and 5 females were used per dose group.
Day |
Dose [mg/kg bw] and cumulative mortality |
||||
25.3 |
98 |
196 |
294 |
335 |
|
Males |
|||||
1 |
0 |
0 |
0 |
0 |
1 |
2 |
0 |
2 |
0 |
2 |
3 |
3 |
0 |
2 |
2 |
3 |
5 |
15 |
0 |
2 |
2 |
3 |
5 |
Females |
|||||
1 |
0 |
0 |
0 |
0 |
1 |
2 |
0 |
3b) |
1 |
3 |
4a) |
3 |
0 |
3 |
3 |
3 |
5 |
4 |
0 |
3 |
3 |
4a) |
5 |
15 |
0 |
3 |
3 |
4 |
5 |
a) one animal was killed in extremis
b) two animals were killed in extremis
Table 2: Mean bodyweight data for surviving rats after single administration of cyhalothrin.
|
Day of weighing, mean bodyweight [g] and number of animals |
Bodyweight gain day 0-15 [g] |
|||||
0 |
1 |
3 |
4 |
8 |
15 |
||
Males |
|||||||
25.3 mg/kg |
147 5 |
131 5 |
157 5 |
164 5 |
198 5 |
256 5 |
109 |
98 mg/kg |
152 3 |
139 3 |
145 3 |
155 3 |
18 3 |
256 3 |
104 |
196 mg/kg |
153 3 |
138 3 |
140 3 |
148 3 |
188 3 |
246 3 |
93 |
294 mg/kg |
173 2 |
150 2 |
137 2 |
152 2 |
193 2 |
266 2 |
93 |
Females |
|||||||
25.3 mg/kg |
140 5 |
124 5 |
147 5 |
150 5 |
169 5 |
200 5 |
60 |
98 mg/kg |
121 2 |
106 2 |
121 2 |
124 2 |
152 2 |
177 2 |
56 |
196 mg/kg |
132 2 |
117 2 |
120 2 |
135 2 |
157 2 |
188 2 |
56 |
294 mg/kg |
141 1 |
123 1 |
119 1 |
131 1 |
159 1 |
206 1 |
65 |
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- The study is considered to be reliable with restrictions.
- Executive summary:
The acute oral toxicity of cyhalothrin was determined in a study similar to OECD 401 and under GLP. Five males and five females were used per dose group.
The LD50 (rat, oral) was determined to be 166 mg/kg bw in males and 114 mg/kg bw in females.
Clinical signs of toxicity were seen in nearly all surviving animals and included decreased activity, dehydration, piloerection, salivation, ungroomed appearance, urinary incontinence, upward curvature of the spine and ataxia.
Based upon the classification criteria according to the Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008, the test item has to be classified as acute toxic category III.
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