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EC number: 607-864-3
CAS number: 26116-57-4
All animals survived till the end of the study.
No abnormal behaviour or clinical signs were detected during the
experiment in the animals.
No local irritations were observed at the application sites of all
animals of all test substance groups and both control groups throughout
the whole study.
Body masses and body mass gains of all animals were in the range to be
expected from animals of the same strain, sex and age. Body weight loss
was noted in 2/5 animals in the high dose treatment group.
The Local Lymph Node Assay was performed according to OECD Guideline 429
and the B.42 EU Method, to evaluate a possible sensitizing potential of
the test substance. The test substance was solved in DMSO and was
administered to three groups of 5 female CBA/Ca mice. Administration was
performed epicutaneously to the dorsal surface of both ears, once a day
on 3 consecutive days. The volume administered was 25 µL/ear. The
concentrations used were: 5, 10 and 26.5 % w/w (solution of the test
substance in DMSO). Two groups with 5 animals each served as positive
and negative controls. Both control substances were administered under
identical conditions as the test substances. The SIs of the tested test
substance concentrations were 4.1 (low dose), 6.6 (mid dose) and 7.9
(high dose) (SIs > 3). According to the OECD Guideline 429 and the EU
Method B.42, the test substance is regarded as a sensitizer in the LLNA.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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