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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1970
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Unpublished study report cited in a peer-reviewed publication

Data source

Reference
Reference Type:
secondary source
Title:
Diaethylcarbonat - Toxikologische Untersuchungen (unpublished report)
Author:
Bayer AG
Year:
1970
Bibliographic source:
BG Chemie (1994) Toxicological Evaluations 7. Potential Health Hazards of Existing Chemicals. Springer Verlag

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
dynamic inhalation apparatus
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Diethyl carbonate
EC Number:
203-311-1
EC Name:
Diethyl carbonate
Cas Number:
105-58-8
Molecular formula:
C5H10O3
IUPAC Name:
diethyl carbonate
Test material form:
aerosol dispenser: not specified
Remarks:
migrated information: aerosol
Details on test material:
no further data

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals or test system and environmental conditions:
Weight at study initiation: 160-200 g

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
not specified
Vehicle:
clean air
Details on inhalation exposure:
Exposure apparatus: dynamic inhalation
Analytical verification of test atmosphere concentrations:
yes
Remarks:
not further specified
Duration of exposure:
7 h
Concentrations:
not further specified
No. of animals per sex per dose:
In total 20 m and 20 f in study
Control animals:
not specified
Details on study design:
not further specified
Statistics:
no data

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 1 268 mg/m³ air (analytical)
Exp. duration:
7 h
Remarks on result:
other: f: >1268 mg/m3; m: >1830 mg/m3
Mortality:
no
Clinical signs:
other: none
Body weight:
no data
Gross pathology:
no data

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: OECD GHS
Conclusions:
In Wistar rats, the 7 h LC50 in females was >1268 mg/m3 and in males >1830 mg/m3. The treatment caused no signs of toxicity or irritant effects.
Executive summary:

In Wistar rats, the 7 h LC50 in females was >1268 mg/m3 and in males >1830 mg/m3. The treatment caused no signs of toxicity or irritant effects.