Registration Dossier
Registration Dossier
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EC number: 700-340-6 | CAS number: 76524-94-2
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
An Ames test according to OECD guideline 471 was performed with and without metabolic activation (Sokolowski 2011). In the plate
incorporation test (experiment I) and the pre-incubation test (experiment II) using Salmonella typhimuriumstrains TA 1535, TA 1537, TA 98, and TA 100, and the Escherichia coli strain WP2 uvrA concentrations of 3, 10, 33, 100, 333, 1000, 2500, and 5000 µg/plate were tested. No toxic effects, evident as a reduction in the number of revertants, occurred in the test groups with and without metabolic activation. Compared to the positive control, that showed an increase of induced revertant colonies, the test item did not induce gene mutations by base pair changes or frameshifts in the genome of the strains used.
Short description of key information:
Ames test: negative
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
According to DSD (67/548/EEC) and CLP (1272/2008/EC) Y-15864 does not meet the criteria to be classified regarding this endpoint.
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