2-(2-(2-butoxyethoxy)ethoxy)ethanol

Health surveillance data

Administrative data

Endpoint:

health surveillance data

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Study period:

1993

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: A reasonably well reported study that conforms to basic scientific principles and contributes to the understanding of the sensitising potential of this substance.

Data source

Reference

Reference Type:

publication

Title:

Can chemicals precipitate dermatitis herpetiformis ?

Author:

Snider RL and Maize JC

Year:

1993

Bibliographic source:

J. Am. Acad. Of Dermatology, 28 (1), 111-112.

Materials and methods

Study type:

health record from industry

Endpoint addressed:

dermal absorption

skin irritation / corrosion

skin sensitisation

Test guideline

Qualifier:

no guideline required

Principles of method if other than guideline:

Not applicable - health record from industry

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

2-butoxyethanol

EC Number:

203-905-0

EC Name:

2-butoxyethanol

Cas Number:

111-76-2

Molecular formula:

C6H14O2

IUPAC Name:

2-butoxyethanol

Details on test material:

An industrial cleaner. Analysis of the mixture showed the presence of 2-butoxyethanol, trisodium phosphate, nonylphenol polyethylene glycol ether, anthraquinone, lemon fragrance and an antifoam agent.

Method

Type of population:

occupational

Ethical approval:

not specified

Details on study design:

Patch testing on unaffected skin of the back was carried out with the individual chemicals of the mixture and at the same concentration than in the mixture (except for 2-butoxyethanol which was diluted to avoid irritation)

Results and discussion

Results:

The substance2-(2-(2-butoxyethoxy)ethoxy)ethanol is an analogue of the test substance used in the study.Two cases of dermatitis herpetiformis (DH) temporally related to the use of a cleaning solution containing 2 -butoxyethanol (2BE) have been reported. Analysis of the mixture showed the presence of 2 -butoxyethanol amongst a number of other materials. Patch testing was carried out with the individual chemicals at the same concentration than in the mixture, except for 2BE which was diluted to avoid irritation). There was no reported reaction to 2 -butoxyethanol in the patch tests whereas some of the other chemicals caused an adverse response.

Applicant's summary and conclusion

Conclusions:

The substance 2-(2-(2-butoxyethoxy)ethoxy)ethanol is an analogue of the test substance used in the study.2-butoxyethanol was not the cause of dermatitis herpetiformis in two occupational case studies.

Executive summary:

The substance2-(2-(2-butoxyethoxy)ethoxy)ethanol is an analogue of the test substance used in the study.Two cases of dermatitis herpetiformis (DH) temporally related to the use of a cleaning solution containing 2 -butoxyethanol (2BE) have been reported. Analysis of the mixture showed the presence of 2 -butoxyethanol amongst a number of other materials. Patch testing was carried out with the individual chemicals at the same concentration than in the mixture, except for 2BE which was diluted to avoid irritation). There was no reported reaction to 2 -butoxyethanol in the patch tests whereas some of the other chemicals caused an adverse response.