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EC number: 205-592-6 | CAS number: 143-22-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1990
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
Materials and methods
- Study type:
- study with volunteers
- Endpoint addressed:
- dermal absorption
- skin irritation / corrosion
- repeated dose toxicity: dermal
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Dermal penetration and irritation study to determine the ability of triethylene glycol monomethyl ether (TGME), triethylene glycol monoethyl ether (TGEE), and TGBE to penetrate human skin and cause systemic toxicity from repeated dermal exposure.
In this experiment, human abdominal whole skin (dermis plus epidermis) samples were assessed in vitro. Skin samples were mounted in a glass diffusion apparatus that exposed 2.54 sq. cm of epidermal area for chemical absorbtion determinations. - GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-(2-(2-butoxyethoxy)ethoxy)ethanol
- EC Number:
- 205-592-6
- EC Name:
- 2-(2-(2-butoxyethoxy)ethoxy)ethanol
- Cas Number:
- 143-22-6
- Molecular formula:
- C10H22O4
- IUPAC Name:
- 2-[2-(2-butoxyethoxy)ethoxy]ethanol
Constituent 1
Method
- Type of population:
- other: human abdominal whole skin (dermis plus epidermis) samples were assessed in vitro.
- Subjects:
- In this experiment, human abdominal whole skin (dermis plus epidermis) samples were assessed in vitro. Skin samples were mounted in a glass diffusion apparatus that exposed 2.54 sq. cm of epidermal area for chemical absorbtion determinations. Samples were tested for integrity (tritiated water diffusion through the skin prior to exposure), diffusion of glycol ethers through the skin, and epidermal damage after chemical exposures (increase in tritiated water diffusion following exposure).
- Ethical approval:
- confirmed, but no further information available
- Route of exposure:
- dermal
- Reason of exposure:
- intentional
- Exposure assessment:
- measured
- Details on exposure:
- Dermal penetration and irritation study to determine the ability of triethylene glycol monomethyl ether (TGME), triethylene glycol monoethyl ether (TGEE), and TGBE to penetrate human skin and cause systemic toxicity from repeated dermal exposure.
In this experiment, human abdominal whole skin (dermis plus epidermis) samples were assessed in vitro. Skin samples were mounted in a glass diffusion apparatus that exposed 2.54 sq. cm of epidermal area for chemical absorbtion determinations. Samples were tested for integrity (tritiated water diffusion through the skin prior to exposure), diffusion of glycol ethers through the skin, and epidermal damage after chemical exposures (increase in tritiated water diffusion following exposure). - Examinations:
- Dermal penetration and irritation study to determine the ability of triethylene glycol monomethyl ether (TGME), triethylene glycol monoethyl ether (TGEE), and TGBE to penetrate human skin and cause systemic toxicity from repeated dermal exposure.
Human abdominal skin (2.54 cm2) was mounted in a glass diffuison apparatus and the diffusion of TEGBE into the donator chamber was monitored during a 12 h-period using gas chromatography.
Results and discussion
- Results of examinations:
- No systemic effects were observed.
The mean steady state of absorption for triethylene glycol monobutyl ether was 22.2 ug/cm sq/hr (SD +/- 8.59), which was 100-fold less than that of ethylene glycol monomethyl ether. Test material did not increase permeability of the membrane (damage ratio of 1.26).
In this experiment, human abdominal whole skin (dermis plus epidermis) samples were assessed in vitro. Skin samples were mounted in a glass diffusion apparatus that exposed 2.54 sq. cm of epidermal area for chemical absorbtion determinations. Samples were tested for integrity (tritiated water diffusion through the skin prior to exposure), diffusion of glycol ethers through the skin, and epidermal damage after chemical exposures (increase in tritiated water diffusion following exposure). The three compounds crossed human epidermis at molar rates 170-330 times slower than the corresponding monoethylene glycol ethers. The skin damage ratio for TGME, however, was comparable to that of ethylene glycol monomethyl ether, indicating that the diffusion barrier function of the skin was slightly diminished after 12 hours of exposure.
Any other information on results incl. tables
In this experiment, human abdominal whole skin (dermis plus epidermis) samples were assessed in vitro. Skin samples were mounted in a glass diffusion apparatus that exposed 2.54 sq. cm of epidermal area for chemical absorbtion determinations. Samples were tested for integrity (tritiated water diffusion through the skin prior to exposure), diffusion of glycol ethers through the skin, and epidermal damage after chemical exposures (increase in tritiated water diffusion following exposure). The three compounds crossed human epidermis at molar rates 170-330 times slower than the corresponding monoethylene glycol ethers. The skin damage ratio for TGME, however, was comparable to that of ethylene glycol monomethyl ether, indicating that the diffusion barrier function of the skin was slightly diminished after 12 hours of exposure.
Applicant's summary and conclusion
- Conclusions:
- The three compounds crossed human epidermis at molar rates 170-330 times slower than the corresponding monoethylene glycol ethers. The skin damage ratio for TGME, however, was comparable to that of ethylene glycol monomethyl ether, indicating that the diffusion barrier function of the skin was slightly diminished after 12 hours of exposure.
No systemic effects were observed. - Executive summary:
Human abdominal skin (2.54 cm2) was mounted in a glass
diffuison apparatus and the diffusion of TEGBE into the
donator chamber was monitored during a 12 h-period using gas
chromatography. The diffusion rate of TEGBE was determined
to be 22 óg/cm2/h indicating a low skin permeability of the
compound.
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