Registration Dossier
Registration Dossier
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EC number: 205-498-5 | CAS number: 141-75-3
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Butyryl chloride
- EC Number:
- 205-498-5
- EC Name:
- Butyryl chloride
- Cas Number:
- 141-75-3
- Molecular formula:
- C4H7ClO
- IUPAC Name:
- butanoyl chloride
- Details on test material:
- - Name of test material (as cited in study report): n-büttersäurechlorid
- Substance number: XXVI 622
- Substance type: liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Wiga
- Weight at study initiation: males: 208 g; females: 176 g
- Diet: Herilan MRH
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 42 cm2 - Duration of exposure:
- 24 hours
- Doses:
- 1000 and 2000 mg/kg bw
- No. of animals per sex per dose:
- 3 (1000 mg/kg bw)
6 (2000 mg/kg bw) - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: daily (except the weekends)
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 0/6 at 1000 mg/kg bw
1/12 at 2000 mg/kg bw - Clinical signs:
- other: Dyspnea (at the start of the study), apathy, aggression, uncoordinated movement, spastic gait, anaemic appearance, poor general condition, local skin irritation converting to necrosis.
- Gross pathology:
- Animals dying during the test: hart: acute atrial dilatation, local acute hyperaemia; liver: anaemia.
Animals sacrificed at the end of the observation period: no abnormalities.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
