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EC number: 203-113-5 | CAS number: 103-45-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23 October 1979 to 20 November 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Standard test method but conducted prior to adoption of standard test guidelines and GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- The test material, phenylethyl acetate, and appropriate standards, were applied to the clipped dorsum of groups of 8 rabbits for 4 hours under individual semi-occlusive patches (8-ply gauze). After removal of the patches, the treated areas were wiped and examined for evidence of irritation. Assessments were made at removal of the dressing, 24, 48 and 72 hours after treatment.
- GLP compliance:
- no
- Remarks:
- :study pre-dates GLP
Test material
- Reference substance name:
- Phenethyl acetate
- EC Number:
- 203-113-5
- EC Name:
- Phenethyl acetate
- Cas Number:
- 103-45-7
- Molecular formula:
- C10H12O2
- IUPAC Name:
- 2-phenylethyl acetate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no details
- Age at study initiation: 9-12 weeks
- Weight at study initiation: no details
- Housing: no details
- Diet (e.g. ad libitum): no details
- Water (e.g. ad libitum): no details
- Acclimation period: no details
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no details
- Humidity (%): no details
- Air changes (per hr): no details
- Photoperiod (hrs dark / hrs light): no details
IN-LIFE DATES: From: 23 October 1979 To: 26 October 1979
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: various positive control tested groups included
- Amount / concentration applied:
- 0.5 ml for each test solution and the standard solutions (diethyl phthalate, cyclamen aldehyde and geraniol) or 0.2g for solid samples.
- Duration of treatment / exposure:
- 4 hours under a semi-occlusive dressing
- Observation period:
- The test material, phenylethyl acetate, and appropriate standards, were applied to the clipped dorsum of groups of 8 rabbits for 4 hours under individual semi-occlusive patches (8-ply gauze). After removal of the patches, the treated areas were wiped and examined for evidence of irritation. Assessments were made at removal of the dressing, 24, 48 and 72 hours after treatment.
- Number of animals:
- 8 New Zealand White rabbits, aged 9-12 weeks were used for each test. The whole dorsal surface was clipped 3-4 days before the test commenced, animals in the telogen phase of hair growth were selected.
- Details on study design:
- Occlusive patches were prepared by attaching a piece of thin flexible polythene 3cm x 3cm to a piece of zinc oxide plaster 9cm x 2.5cm. A 2.5cm square of cotton gauze (8 ply folded in two) was laid on the polythene such that the edges of the pad are attached to the zinc oxide plaster. Test solutions (0.5ml) were applied to the dry patch. (Test solids (0.2g) were applied to a moistened patch.) {Aerosol preparations were applied directly to the skin with two 1-second bursts and the patches were saturated with spray which acted as a reservoir.}
The patches were firmly attached to ensure good contact between the skin and test substance. The animals were immobilised in a canvas body sleeve for 4 hours after application of the patch. When the patches were removed, the treatment sites were wiped clean of excess material. The positions of treatment sites were randomised
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 72 hours
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- other: marginal reactions recorded, wich resolved within the observation period, and which were much less distinct than these elicted by the positive control standards
- Irritant / corrosive response data:
- For phenylethyl acetate erythema and oedema reactions were marginal, very slight or slight predominantly at the 4 and 24 hour assessments with amelioration and resolution by the 48 and 72 hour assessments.
- Other effects:
- No dermal reactions other than marginal to slight erythema and oedema
Any other information on results incl. tables
No further details
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- For phenylethyl acetate erythema and oedema reactions were marginal, very slight or slight predominantly at the 4 and 24 hour assessments with amelioration and resolution by the 48 and 72 hour assessments.
- Executive summary:
Skin irritation to the rabbit. A study was conducted to investigate the irritation effects of test materials (including phenylethyl acetate) when applied once to intact skin under a semi-occlusive dressing. A 4-hour semi-occlusive patch test was conducted on eight New Zealand white rabbits, 9 - 12 weeks old. The dorsal region was clipped 3-4 days before the beginning of the study. A 0.5-ml aliquot of the undiluted test material, and appropriate standards, were applied to gauze pads attached to strips of adhesive tape. The patches were placed on the clipped dorsum of animals, and the animals were then immobilized in body sleeves for 4 hours. After removal of the patches, the sites were wiped clean of the excess test material. Reactions were graded immediately and at 24, 48 and 72 hours after patch removal. For phenylethyl acetate erythema and oedema reactions were marginal, very slight or slight predominantly at the 4 and 24 hour assessments with amelioration and resolution by the 48 and 72 hour assessments. The results of this study indicate that phenylethyl acetate does not require classification as a skin irritant according to the CLP Regulation.
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