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Diss Factsheets
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EC number: 203-113-5 | CAS number: 103-45-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The skin irritation study reports only minor transient effects. Although there is a lack of detail in reporting, the results are supported by the presence of minimal effects in the acute dermal toxicity study at dose levels well in excess of the limit dose. It can therefore be concluded that phenylethyl acetate does not require classification as a skin irritant. Although relatively mild signs of eye irritation seen in a rabbit study are not of sufficient magnitude to trigger classification, the absence of any evidence of reversibility within the 7-day study period triggers classification as a Category 1 eye irritant according to the CLP criteria.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In vitro assessment of skin irritation or corrosivity potential was not required since in vivo administration of three doses to rabbits revealed 24 hour exposure to phenylethyl acetate at 6500, 10000 or 15000 mg/kg elicited no more than transient very slight erythema that resolved rapidly.
The key study of irritation also demonstrated a lack of dermal reactions. In a group of eight rabbits treated with phenylethyl acetate for 4 hours under a semi-occlusive dressing, marginal or slight erythema and oedema were observed up to 24 hours after dosing but reactions had reversed within 72 hours.
No in vitro assessment of ocular irritation/corrosivity was necessary since the in vivo study indicated persistent ocular reactions in rabbits that would necessitate classification as 'Risk of serious damage to eyes'. Despite ocular reactions not being very severe, and the mean scores over the 24 -72 hour period would not exceed classification thresholds, but the study was terminated on day 7 and reactions persisted in the rabbits at the time of termination. Since reversibility could not be confirmed, it is necessary to default to the Cat.1 classification for eye irritation under Regulation 1272/2008, 2nd ATP (Commission Regulation (EU) No. 286/2011 of 10 March 2011). This equates to the R41 "risk of serious damage to eyes" classification under the DPD.
Justification for selection of skin irritation / corrosion endpoint:
Only one standard study available for this endpoint
Justification for selection of eye irritation endpoint:
Only one study available
Effects on eye irritation: highly irritating
Justification for classification or non-classification
There is no indication from a skin irritation study or from an acute dermal toxicity study that phenyl ethyl acetate requires classification as a skin irritant. The absence of reversibility in the eye irritation study warrants classification of phenyl ethyl acetate as a Category 1 eye irritant according to CLP criteria, H318 causes serious eye damage.
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