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Diss Factsheets
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EC number: 248-470-8 | CAS number: 27458-93-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
No reliable guideline-standard measured bioconcentration studies are available. Based on the available predicted log Kow of 6.1 - 7.6 for the constituents, the substance could be considered to be potentially bioaccumulative. However, the rapid biodegradation of the substance (see section 5.2), combined with evidence of rapid metabolism in fish, mammals and micro-organism studies (Mankura (1987), and see Sections 7.1, 6.1.5), suggest that this would be an overly conservative interpretation, and that it is unlikely that bioaccumulation would be seen in studies. Furthermore, conducting guideline-standard studies of bioaccumulation in fish would be confounded by the technical difficulties of maintaining the test alcohols in solution. As was demonstrated in the long-term studies of effects in invertebrates (see IUCLID Section 6.1.2). Severe difficulties were encountered in conducting the study as biodegradation of the substance in the test system was almost complete within the 24 h test media renewal period.
BCF has been calculated using SRC BCFBAF v3.01 (EPA 2011). The model uses a log Kow-based equation with modified algorithms for specific structural features. The software also incorporates a modification for biotransformation in vivo which in an important property of the alcohols. Predicted BCF values of 680 - 1000 (depending on trophic level) for C14, 580 - 930 for C16 (linear and branched), 200 - 380 for C18 (linear and branched) and 44 - 85 for C20 (linear and branched) were determined.
However, it is evident that, even allowing for biotransformation, the predicted BCF values indicate a very significant overestimate compared to experimental values. For example, BCFBAF prediction for hexadecan-1-ol gives BCF values of 590 to 890, depending on trophic level, whereas there is non-guideline-standard measured BCF value of 60 available (Freitag et al., 1985).
Rapid biotransformation of C18 -unsaturated alcohol into tissue lipids has been demonstrated by Mankura (1987) in fish (carp).
The weight of evidence indicates that the constituents of Fatty alcohols C16 – C18 (even numbered), branched and linear,will not bioaccumulate.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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