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EC number: 203-040-9 | CAS number: 102-56-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well performed GLP and OECD guideline study, but positive control data not available
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Deviations:
- yes
- Remarks:
- (positive control data not available)
- GLP compliance:
- yes
- Type of study:
- Buehler test
Test material
- Reference substance name:
- 2,5-dimethoxyaniline
- EC Number:
- 203-040-9
- EC Name:
- 2,5-dimethoxyaniline
- Cas Number:
- 102-56-7
- Molecular formula:
- C8H11NO2
- IUPAC Name:
- 2,5-dimethoxyaniline
- Details on test material:
- - Name of test material (as cited in study report): Aminohydrochinondimethylether
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- other: Pirbright-White guinea pig
- Sex:
- female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: HOECHST AG, breeding colony
- Weight at study initiation: 275 - 357 g
- Housing: in fully air·conditioned rooms in Makrolon cages on soft wood granulate, in groups of 5 animals
- Diet (e.g. ad libitum): Standard feed for guinea pigs and rabbits (Altromin 3112), ad libitum
- Water (e.g. ad libitum): tap water, ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +-3
- Humidity (%): 50 +-20
- Photoperiod (hrs dark / hrs light): 12/12
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- other: deionisied water
- Concentration / amount:
- Determination of the primary non·irritant concentration: 0.5 g Aminohydrochinondimethylether moistened with 0.35 mL deionised water
Induction treatment: 0.5 g Aminohydrochinondimethylether moistened with 0.35 mL deionised water
Challenge treatment: 0.5 g Aminohydrochinondimethylether moistened with 0.35 mL deionised water
Challengeopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- other: deionisied water
- Concentration / amount:
- Determination of the primary non·irritant concentration: 0.5 g Aminohydrochinondimethylether moistened with 0.35 mL deionised water
Induction treatment: 0.5 g Aminohydrochinondimethylether moistened with 0.35 mL deionised water
Challenge treatment: 0.5 g Aminohydrochinondimethylether moistened with 0.35 mL deionised water
- No. of animals per dose:
- Determination of primary non-irritant concentration: 2 animals
Control group: 10 animals
Treated group: 20 animals - Details on study design:
- Main test
Day 1-15
During this test phase, the following procedures were carried out once a week. For the dermal treatments, 0.5 g Aminohydrochinondimethylether moistened with 0.35 mL deionised water was applied in evenly over a 2 x 2 cm cellulose patch, which was fixed to the front part of the left flank of the 20 animals of the treatment group and then covered with an occlusive polyethylene film and a bandage. 10 control animals were treated analogously with 0.5 mL deionised water. After an exposure period of 6 hours the occlusive bandage was removed and the flank skin washed. Clinical signs and irritant effects emerging during the sensitization phase were recorded.
Day 16-28
Animals under observation
Day 29
Challenge treatment.This took place under identical conditions for control and treated animals alike. The hair of the previously untreated right flank was removed mechanically. Challenge treatment was performed with 0.5 g Aminohydrochinondimethylether moistened with 0.35 mL deionised water. The test substance preparation was applied to a cellulose patch, which was placed on the hind part of the right flank and covered with an occlusive bandage. Exposure was for 6 hours. After removal of the occlusive bandage, any remnants of the substance were carefully washed off with warm water.
Day 30
Macroscopic examination of the skin.
Day 31
Macroscopic examination of the skin. Terminal body weight determination. - Positive control substance(s):
- not specified
Results and discussion
- Positive control results:
- Not reported in this study report. It is likely that positive control results are reported separately.
In vivo (non-LLNA)
Resultsopen allclose all
- Reading:
- other: reading after 1st treatment
- Group:
- negative control
- Dose level:
- 0
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- none
- Remarks on result:
- other: Reading: other: reading after 1st treatment. Group: negative control. Dose level: 0. No with. + reactions: 0.0. Total no. in groups: 10.0. Clinical observations: none.
- Reading:
- other: reading after 1st treatment
- Group:
- test chemical
- Dose level:
- 0.5 g
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Clinical observations:
- none
- Remarks on result:
- other: Reading: other: reading after 1st treatment. Group: test group. Dose level: 0.5 g. No with. + reactions: 0.0. Total no. in groups: 20.0. Clinical observations: none.
- Reading:
- other: reading after 2nd treatment
- Group:
- negative control
- Dose level:
- 0
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- none
- Remarks on result:
- other: Reading: other: reading after 2nd treatment. Group: negative control. Dose level: 0. No with. + reactions: 0.0. Total no. in groups: 10.0. Clinical observations: none.
- Reading:
- other: reading after 2nd treatment
- Group:
- test chemical
- Dose level:
- 0.5 g
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Clinical observations:
- none
- Remarks on result:
- other: Reading: other: reading after 2nd treatment. Group: test group. Dose level: 0.5 g. No with. + reactions: 0.0. Total no. in groups: 20.0. Clinical observations: none.
- Reading:
- other: reading after 3rd treatment
- Group:
- negative control
- Dose level:
- 0
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- none
- Remarks on result:
- other: Reading: other: reading after 3rd treatment. Group: negative control. Dose level: 0. No with. + reactions: 0.0. Total no. in groups: 10.0. Clinical observations: none.
- Reading:
- other: reading after 3rd treatment
- Group:
- test chemical
- Dose level:
- 0.5 g
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Clinical observations:
- none
- Remarks on result:
- other: Reading: other: reading after 3rd treatment. Group: test group. Dose level: 0.5 g. No with. + reactions: 0.0. Total no. in groups: 20.0. Clinical observations: none.
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- negative control
- Dose level:
- 0
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- none
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: negative control. Dose level: 0. No with. + reactions: 0.0. Total no. in groups: 10.0. Clinical observations: none.
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 0.5 g
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Clinical observations:
- none
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: test group. Dose level: 0.5 g. No with. + reactions: 0.0. Total no. in groups: 20.0. Clinical observations: none.
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- negative control
- Dose level:
- 0
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- none
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 48.0. Group: negative control. Dose level: 0. No with. + reactions: 0.0. Total no. in groups: 10.0. Clinical observations: none.
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 0.5 g
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Clinical observations:
- none
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 48.0. Group: test group. Dose level: 0.5 g. No with. + reactions: 0.0. Total no. in groups: 20.0. Clinical observations: none.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
- Conclusions:
- Based on the results of this study Aminohydrochinondimethylether showed no evidence for sensitizing properties.
- Executive summary:
Testing for sensitizing properties of Aminohydrochinondimethylether was performed in female guinea pigs according to OECD 406, method of BUEHLER. Dermal induction was performed using 100 % Aminohydrochinondimethylether (moistened with deionised water) . The control group was exposed to deionised water only. Challenge treatment was carried out with 100 % Aminohydrochinondimethylether (moistened with deionised water). Based on the results of this study Aminohydrochinondimethylether showed no evidence for sensitizing properties.
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