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Diss Factsheets
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EC number: 203-040-9 | CAS number: 102-56-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable study report which meets basic scientific principles. Study was conducted prior to GLP and OECD guideline implementation.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: company guideline similar to OECD 401
- Principles of method if other than guideline:
- Only females were tested. The LD50 was determined according to the method of Kärber.
- GLP compliance:
- no
- Remarks:
- prior to GLP implementation
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,5-dimethoxyaniline
- EC Number:
- 203-040-9
- EC Name:
- 2,5-dimethoxyaniline
- Cas Number:
- 102-56-7
- Molecular formula:
- C8H11NO2
- IUPAC Name:
- 2,5-dimethoxyaniline
- Details on test material:
- - Name of test material (as cited in study report): Aminohydrochinondimethyläther
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 90 -116 g
- Fasting period before study: 16 h
- Diet (e.g. ad libitum): standard feed (ALTROMIN R), ad libitum
- Water (e.g. ad libitum): tap water, ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: mucous starch
- Details on oral exposure:
- - Concentration in vehicle: 4%
- Route: oral, gavage - Doses:
- 250, 400, 630, 1000 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 578 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 250 mg/kg bw: 0/10
400 mg/kg bw: 3/10
630 mg/kg bw: 6/10
1000 mg/kg bw: 10/10
The animals died within 1- 96 hours after application. - Clinical signs:
- other: Animals that died showed disequilibrium, lateral or prone position, narcosis-like state and physical poor health.
- Gross pathology:
- Cross pathology of animals found dead didn't reveal any abnormal findings.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- LD50: 578 mg/kg bw.
- Executive summary:
Acute toxicity of Aminohydrochinondimethyläther was tested according to a company guideline reasonably similar to OECD 401. Following this protocol doses of 250, 400, 630, 1000 mg/kg bw were administered by gavage to 10 female rats per dose.
During the observation period of 14 days mortality occured at doses of 400 mg/kg bw (3/10), 630 mg/kg bw (6/10), and 1000 mg/kg bw (10/10). LD50 was calculated to be 578 mg/kg bw.
Animals that died showed disequilibrium, lateral or prone position, narcosis-like state and physical poor health. Cross pathology of animals found dead didn't reveal any abnormal findings.
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