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EC number: 406-420-4 | CAS number: 69430-40-6 DC 5067
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 January - 25 June, 1991
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.7 (Repeated Dose (28 Days) Toxicity (Oral))
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 407 (Repeated Dose 28-Day Oral Toxicity Study in Rodents)
- GLP compliance:
- yes
- Limit test:
- yes
Test material
- Reference substance name:
- α-trimethylsilanyl-ω-trimethylsiloxypoly[oxy(methyl-3-(2-(2-methoxypropoxy)propoxy)propylsilanediyl]-co-oxy(dimethylsilane))
- EC Number:
- 406-420-4
- EC Name:
- α-trimethylsilanyl-ω-trimethylsiloxypoly[oxy(methyl-3-(2-(2-methoxypropoxy)propoxy)propylsilanediyl]-co-oxy(dimethylsilane))
- Cas Number:
- 69430-40-6
- Molecular formula:
- Unspecified example: C18.3H46.8O5.8Si4.1
- IUPAC Name:
- 2,2,4,4,6,12,15-heptamethyl-6-[(trimethylsilyl)oxy]-3,5,10,13,16-pentaoxa-2,4,6-trisilaheptadecane
- Details on test material:
- Identification: DC 5067
Description: Clear, light brown liquid
Lot Number: AB 090122
Purity: >99%
Storage conditions: In the original container at room temperature in the dark
Stability under storage conditions: Stab1e
Expiry date: December 1, 1991
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- 28 days
- Frequency of treatment:
- Once daily, approximately the same time each day, 7 days per week
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
Dose Levels: 0 (distilled water), 300, 600, 1000 mg/kg b.w./day
Basis:
actual ingested
- Remarks:
- Doses / Concentrations:
Dose volume: 1.05 (distilled water, 0.32, 0.63, 1.05 mg/kg b.w./day
Basis:
actual ingested
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
Results and discussion
Effect levels
- Dose descriptor:
- NOEL
- Effect level:
- 300 mg/kg bw/day (nominal)
- Sex:
- male/female
- Basis for effect level:
- other: see 'Remark'
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Oral treatment with DC 5067 resulted in excessive salivation in all treated animals, which was noted from the end of week 1 until termination. However, as this may be attributable to an irritant effect or a bad taste of the test substance, it was considered not to be representativ e of toxicity. statistical significant increases were noted in liver, heart, ki spleen weights after correction for body weight. In the absence corroborrative findings-i,n..clinical pathology or histopathology, toxicological significance of these findings may be considered questionable, although general consistency of effect between males and females should be noted. dney and of any the There were no changes in body weights, food consumption, ophthalmoscopic examination, clinical laboratory investigations, macroscopic examination and microscopic examination that were considered to be an effect of treatment. At the treatment level used a No Observed Effect Level of 300 mg/kg/day was established.
Applicant's summary and conclusion
- Conclusions:
- From the results Presented in this report a definitive No Observed Effect Level (NOEL) of 300 mg/kg/day was established.
- Executive summary:
RATIONALE FOR DOSE LEVEL SELECTION
A 5-day range finding study was performed (with 3 rats/sex/group at dose level.5 Of 300, 600 and 1000 mg/kg/day) to provide a basis for selection of dose levels for a study of longer duration. ~0 differences of biological significance were observed in clinical appearance, body weight, food consumption, macroscopic appearance or liver weights between the treated groups. Based on these observations, a high treatment level of 1000 mg/kg/day was selected for a study of 28 days duration.
METHODOLOGY
In this subacute 28-day toxicity study, DC 5067 was administered daily by gavage to SPF-bred Wistar rats. The study comprised of four 'groups. The number of rats assigned to toxicity testing per group as well as the dose levels administered were as follows:
The number of rats assigned to toxicity testing per group as well as the dose levels administered were as follows:
Total number of animals: 40 (20 males, 20 females), Total number of animals per group: 5 males, 5 females
Dose levels: 0 mg/kg, 300 mg/kg, 600 mg/kg, 1000 mk/kg
FINDINGS
At 300 mg/kg/day: No treatment-related changes noted.
At 600 mg/kg/day: Increased relative liver weights were noted in females and relative spleen weights were noted in males.
At 1000 mg/kg/day: Increased relative heart weights were noted in females only and increased relative liver or spleen weights were noted in males and females.
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