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EC number: 236-152-1 | CAS number: 13194-48-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1977-04-26 to 1977-04-27
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- test item applied to abraded and non-abraded skin
- Qualifier:
- according to guideline
- Guideline:
- other: CFR section 1500.41
- Deviations:
- no
- GLP compliance:
- no
Test material
- Reference substance name:
- Ethoprophos
- EC Number:
- 236-152-1
- EC Name:
- Ethoprophos
- Cas Number:
- 13194-48-4
- Molecular formula:
- C8H19O2PS2
- IUPAC Name:
- ethyl bis(propylsulfanyl)phosphinate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: not specified
- Age at study initiation: not specified
- Weight at study initiation: 2.0 - 2.5 kg
- Housing: individually, no further specification
- Diet (ad libitum): not specified
- Water (ad libitum): yes, except 24 h exposure period
- Acclimation period: not specified
ENVIRONMENTAL CONDITIONS
not specified
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: clipped and abraded
- Remarks:
- clipped before
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.5 mL - Duration of treatment / exposure:
- 24 h
- Observation period:
- 72 h
- Number of animals:
- 6 animals
- Details on study design:
- TEST SITE
- Area of exposure: dorsum
- Type of wrap: inch gauze patch held in place with Dermicel tape. The trunks of the animals were wrapped with rubberized cloth.
REMOVAL OF TEST SUBSTANCE
not specified
OBSERVATION TIME POINTS
24 and 48 h
SCORING SYSTEM: Scoring of erythema, eschar and edema for calculation of primary irritation index
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Max. score:
- 4
- Remarks on result:
- not determinable
- Remarks:
- due to acute toxicity (mortality) within 8 h
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Max. score:
- 4
- Remarks on result:
- not determinable
- Remarks:
- due to acute toxicity (mortality) within 8 h
- Irritant / corrosive response data:
- Dermal irritation could not be determined in this study.
- Other effects:
- - Other adverse local effects:
All animals experienced salivation, loss of righting reflex, tremors and mortality within the first 8 hours.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- Under the test condition, the test item was not irritating to the skin of the rabbit. Nevertheless all animals died before the end of the observation period due to the high dermal toxicity of the test item in the rabbit. Due to the high acute dermal toxicity of the test item to the rabbit, the primary skin irritating property was not further investigated.
- Executive summary:
In a 1977 study similar to OECD 404, 0.5 mL undiluted test substance was applied under occlusive conditions to the intact or abraded shorn dorsal skin of 6 male New Zealand White rabbits for 24 hours.
Signs of toxicity (salivation, loss of righting reflex and tremors) occurred within 8 hours of administration and all animals died within 24 hours. Dermal irritation could not be determined in this study.
Under the test condition, the test item was not irritating to the skin of the rabbit. Nevertheless all animals died before the end of the observation period due to the high dermal toxicity of the test item in the rabbit. Due to the high acute dermal toxicity of the test item to the rabbit, the primary skin irritating property was not further investigated.
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